Evidence map›Paper›PMID 35211363›Full record

ArticleIEEE access : practical innovations, open solutions2021

Scale-Aware Transformers for Diagnosing Melanocytic Lesions.

Wenjun Wu, Sachin Mehta, Shima Nofallah, Stevan Knezevich, Caitlin J May, Oliver H Chang, Joann G Elmore, Linda G Shapiro

Abstract read
In one paragraph

Article in IEEE access : practical innovations, open solutions, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Machine learning classification of diagnostic accuracy in pathologists interpreting breast biopsies.Journal of the American Medical Informatics Association : JAMIA · 2024
    Article
  6. Quilt-1M: One Million Image-Text Pairs for Histopathology.Advances in neural information processing systems · 2023
    Article
  7. Transformer-Based Approach to Melanoma Detection.Sensors (Basel, Switzerland) · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Automated analysis of whole slide digital skin biopsy images.Frontiers in artificial intelligence · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenjun WuDepartment of Medical Education and Biomedical Informatics, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0003-2598-9073
Sachin MehtaDepartment of Electrical and Computer Engineering, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-5420-4725
Shima NofallahDepartment of Electrical and Computer Engineering, University of Washington, Seattle, WA 98195, USA.
Stevan KnezevichPathology Associates, Clovis, CA 93611, USA.ORCID 0000-0002-0443-2201
Caitlin J MayDermatopathology Northwest, Bellevue, WA 98005, USA.
Oliver H ChangDepartment of Pathology, University of Washington, Seattle, WA 98195, USA.
Joann G ElmoreDavid Geffen School of Medicine, UCLA, Los Angeles, CA 90024, USA.ORCID 0000-0002-7311-6835
Linda G ShapiroDepartment of Medical Education and Biomedical Informatics, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-9495-0968

Funding

Improving Melanoma Pathology Accuracy through Computer Vision Techniques - the IMPACT StudyR01CA200690 · NCI · UNIVERSITY OF WASHINGTON · PI ELMORE, JOANN G, SHAPIRO, LINDA · 2016 to 2020
$1.9M
A Unified Machine Learning Package for Cancer DiagnosisU01CA231782 · NCI · UNIVERSITY OF WASHINGTON · PI ELMORE, JOANN G, SHAPIRO, LINDA · 2018 to 2020
$980k
NCI NIH HHS R01 CA200690NCI NIH HHS U01 CA231782
6 · The paper itself

Abstract

Diagnosing melanocytic lesions is one of the most challenging areas of pathology with extensive intra- and inter-observer variability. The gold standard for a diagnosis of invasive melanoma is the examination of histopathological whole slide skin biopsy images by an experienced dermatopathologist. Digitized whole slide images offer novel opportunities for computer programs to improve the diagnostic performance of pathologists. In order to automatically classify such images, representations that reflect the content and context of the input images are needed. In this paper, we introduce a novel self-attention-based network to learn representations from digital whole slide images of melanocytic skin lesions at multiple scales. Our model softly weighs representations from multiple scales, allowing it to discriminate between diagnosis-relevant and -irrelevant information automatically. Our experiments show that our method outperforms five other state-of-the-art whole slide image classification methods by a significant margin. Our method also achieves comparable performance to 187 practicing U.S. pathologists who interpreted the same cases in an independent study. To facilitate relevant research, full training and inference code is made publicly available at https://github.com/meredith-wenjunwu/ScATNet.

Indexed as

Convolutional neural networkhistopathological imagesmelanocytic risk lesionsmelanomamulti-scaleskin cancer diagnosistransformerswhole-slide image classification

Identifiers

PMID35211363
PMCPMC8865389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.