Evidence map›Paper›PMID 35211240›Full record

ReviewOxidative medicine and cellular longevity2022

The Role of Bioactive Compounds in Natural Products Extracted from Plants in Cancer Treatment and Their Mechanisms Related to Anticancer Effects.

Meng Yuan, Guoqing Zhang, Weijun Bai, Xin Han, Chan Li, Siman Bian

Open access · hybridAbstract readReview
In one paragraph

Review in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Antibacterial and Anticancer Potential ofInternational journal of molecular sciences · 2026
    Article
  6. Plant-Derived Bioactive Compounds and Their Therapeutic Potential in Cancer.International journal of molecular sciences · 2026
    Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. In silico approach andContemporary oncology (Poznan, Poland) · 2026
    Article
  14. Food & nutrition research · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Meng YuanMedical Oncology Department of Thoracic Cancer (3), Liaoning Cancer Hospital & Institute (Cancer Hospital of China Medical University), No. 44 Xiaoheyan Road, Dadong District, Shenyang City, 110042 Liaoning Province, China.ORCID https://orcid.org/0000-0003-0001-3453
Guoqing ZhangDepartment of Thoracic Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China 450052.ORCID https://orcid.org/0000-0001-5388-0812
Weijun BaiMedical Oncology Department of Thoracic Cancer (3), Liaoning Cancer Hospital & Institute (Cancer Hospital of China Medical University), No. 44 Xiaoheyan Road, Dadong District, Shenyang City, 110042 Liaoning Province, China.ORCID https://orcid.org/0000-0001-8645-7439
Xin HanMedical Oncology Department of Thoracic Cancer (3), Liaoning Cancer Hospital & Institute (Cancer Hospital of China Medical University), No. 44 Xiaoheyan Road, Dadong District, Shenyang City, 110042 Liaoning Province, China.ORCID https://orcid.org/0000-0003-2165-4962
Chan LiMedical Oncology Department of Thoracic Cancer (3), Liaoning Cancer Hospital & Institute (Cancer Hospital of China Medical University), No. 44 Xiaoheyan Road, Dadong District, Shenyang City, 110042 Liaoning Province, China.ORCID https://orcid.org/0000-0002-9634-7329
Siman BianMedical Oncology Department of Thoracic Cancer (3), Liaoning Cancer Hospital & Institute (Cancer Hospital of China Medical University), No. 44 Xiaoheyan Road, Dadong District, Shenyang City, 110042 Liaoning Province, China.ORCID https://orcid.org/0000-0002-6895-6602
Liaoning Cancer Hospital & Institute · CNFirst Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is one of the greatest causes of death worldwide. With the development of surgery, radiotherapy, and medical agents, the outcomes of cancer patients have greatly improved. However, the underlying mechanisms of cancer are not yet fully understood. Recently, natural products have been proven to be beneficial for various conditions and have played important roles in the development of novel therapies. A substantial amount of evidence indicates that bioactive compounds could improve the outcomes of cancer patients via various pathways, such as endoplasmic reticulum stress, epigenetic modification, and modulation of oxidative stress. Here, we review the current evidence of bioactive compounds in natural products for the treatment of cancer and summarize the underlying mechanisms in this pathological process.

Indexed as

Angiogenesis InhibitorsAnimalsAntineoplastic AgentsAntioxidantsBiological ProductsEndoplasmic Reticulum StressEpigenesis, GeneticGastrointestinal MicrobiomeHumansNeoplasmsPlant ExtractsTranscription FactorsAngiogenesis InhibitorsAntineoplastic AgentsAntioxidantsBiological ProductsPlant ExtractsTranscription Factors

Identifiers

PMID35211240
PMCPMC8863487
OpenAlexW4214732035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.