Evidence map›Paper›PMID 35211094›Full record

SynthesisFrontiers in endocrinology2022

Dissecting the Association of Apolipoprotein E Gene Polymorphisms With Type 2 Diabetes Mellitus and Coronary Artery Disease.

Lei Wu, Yan Zhang, Hong Zhao, Guodong Rong, Peijun Huang, Fang Wang, Ting Xu

Open access · goldAbstract readMeta-Analysis
In one paragraph

Synthesis in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Exploring the role of apolipoprotein ε4 in progressive myoclonic epilepsy type 1.Epileptic disorders : international epilepsy journal with videotape · 2026
    Article
  4. Article
  5. Genes · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Evidence from genetic studies among rs2107538 variant in theSaudi journal of biological sciences · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lei WuDepartment of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yan ZhangDepartment of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Hong ZhaoDepartment of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Guodong RongDepartment of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Peijun HuangDepartment of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Fang WangDepartment of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Ting XuDepartment of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Jiangsu Province Hospital · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Apolipoprotein E ( Methods: A total of 1,414 subjects involving 869 patients and 545 health individuals were recruited. These patients were categorized into three distinct groups: 264 in T2DM group, 401 in CAD group, and 204 in T2DM+CAD group. Logistic regression analysis was used to obtain odds ratio (OR) and 95% confidence interval (CI) in predicting the risk probability of Results: Genotype frequency ratio of genotype ϵ3/4 and allele ϵ4 among the CAD patients with or without T2DM was obviously increased. Compared with ϵ3/3 genotype, the ϵ3/4 genotype had a significant increased risk of CAD (adjusted OR = 1.90, 95% CI = 1.30-2.77) and T2DM+CAD (adjusted OR = 1.95, 95% CI = 1.24-3.08). In the meta-analysis, four studies were included and provided a strong evidence for the Conclusions: Our results indicate that

Indexed as

Apolipoproteins ECoronary Artery DiseaseDiabetes Mellitus, Type 2Gene FrequencyGenetic Predisposition to DiseaseHumansPolymorphism, GeneticApolipoproteins Eapolipoprotein Ecoronary artery diseasemeta-analysispolymorphismtype 2 diabetes mellitus

Identifiers

PMID35211094
PMCPMC8861372
OpenAlexW4210869810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.