ArticleFrontiers in neurology2021
Multimodal Evoked Potentials as Potential Biomarkers of Disease Activity in Patients With Clinically Isolated Syndrome.
Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- VEP Abnormalities in Treatment-Naïve CIS/Early RRMS Without Prior Optic Neuritis: Clinical, Radiological, and CSF Associations.Medicina (Kaunas, Lithuania) · 2026Article
- Selective loss of ulnar somatosensory evoked potentials revealing a focal cervical cord plaque in multiple sclerosis.Clinical neurophysiology practice · 2026Article
- Early prediction of unfavorable evolution after a first clinical episode suggestive of multiple sclerosis: the EUMUS score.Journal of neurology · 2024Article
- Multiple Sclerosis: New Insights into Molecular Pathogenesis and Novel Platforms for Disease Treatment.Current drug research reviews · 2024Review
- Neuroimaging Technology in Exercise Neurorehabilitation Research in Persons with MS: A Scoping Review.Sensors (Basel, Switzerland) · 2023Article
- Evaluation of Event-Related Potentials in Assessing Cognitive Functions of Adult Patients with Epilepsy of Unknown Etiology.Journal of clinical medicine · 2023Article
- The Usefulness of Optical Coherence Tomography in Disease Progression Monitoring in Younger Patients with Relapsing-Remitting Multiple Sclerosis: A Single-Centre Study.Journal of clinical medicine · 2022Article
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Authors and funding
7 authors.
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Abstract
objectiveThere is an ongoing search for markers useful in monitoring and predicting disease activity at the early stage of multiple sclerosis (MS). The goals of this study were to prospectively evaluate the changes in parameters of multimodal evoked potentials (EP) and cognition within a 3-year follow-up period in patients with clinically isolated syndrome (CIS), and to assess the prognostic value of baseline findings with regard to the disease outcomes.
methodsIn 29 patients (20 women, nine men, mean age 31.1) multimodal (visual, brainstem auditory, somatosensory, event-related) EP and neuropsychological tests (NT) were performed at baseline (T0) and after 1 (T1) and 3 (T3) years. Their results were compared longitudinally between baseline, T1, and T3. Baseline results confirmed conversion of CIS into multiple sclerosis (MS) and disability level at T1 and T3 using multiple comparisons and a logistic regression model.
resultsApart from mean N13/P16 SEP (somatosensory evoked potentials) amplitude (lower at T1 and T3 than at baseline (T0 1.02 ± 0.37 μV, T1 0.90 ± 0.26 μV, T3 0.74 ± 0.32 μV, SIGNIFICANCE: Baseline ERP abnormalities were associated with their short-term conversion into MS. ERP are worth considering in multimodal EP evaluation at the early stage of MS.
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