ArticleFrontiers in psychiatry2021
The Function and Structure of Precuneus Is Associated With Subjective Sleep Quality in Major Depression.
Article in Frontiers in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Multimodal integration of homotopic connectivity and transcriptomic signatures in major depressive disorder with sleep disorder comorbidity.BMC psychiatry · 2025Article
- GWAS by Subtraction to Disentangle RBD Genetic Background from α-Synucleinopathies.International journal of molecular sciences · 2025Article
- Suprachiasmatic nucleus functional connectivity related to insomnia symptoms in adolescents with major depressive disorder.Frontiers in psychiatry · 2023Article
- Regional homogeneity alterations of resting-state functional magnetic resonance imaging of chronic rhinosinusitis with olfactory dysfunction.Frontiers in neuroscience · 2023Article
- The nucleus accumbens functional connectivity in patients with insomnia using resting-state fMRI.Frontiers in neuroscience · 2023Article
- Neuroimaging signatures and a deep learning modeling for early diagnosing and predicting non-pharmacological therapy success for subclinical depression comorbid sleep disorders in college students.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
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Abstract
backgroundPoor sleep quality is related to depression. However, the investigation of the neural basis for poor sleep quality in individuals with major depression (MD) is limited.
methodsResting state functional and structural MRI data were derived from 114 MD individuals and 74 normal controls (NCs). Fractional amplitude of low-frequency fluctuation (fALFF) and gray matter volume (GMV) were used to measure function and structure of the brain. Pittsburgh Sleep Quality Index (PSQI) was performed to evaluate subjective sleep quality. Correlations were carried out to investigate links of PSQI score with brain imaging indices in MD and NCs, separately. We also examined the differences in fALFF and GMV of brain regions related to PSQI score between MD and NCs.
resultsIn contrast to NCs, MD individuals had higher PSQI score. The higher PSQI score was associated with lower fALFF and lower GMV in bilateral precuneus in MD individuals. Moreover, the MD individuals exhibited increased fALFF in bilateral precuneus compared with NCs. However, the correlation between subjective sleep quality and neuroimaging parameters was not significant in NCs.
conclusionThe implication of these findings is that the function and structure of precuneus provides a neural basis for subjective poor sleep quality in MD. Understanding this may lead to better intervention of depression and associated sleep complaints.
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