ReviewJournal of asthma and allergy2022
Sex Disparities in Asthma Development and Clinical Outcomes: Implications for Treatment Strategies.
Review in Journal of asthma and allergy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Effectiveness of a home-based exercise program on functional outcomes in women with asthma: A randomized controlled trial.BMC pulmonary medicine · 2026Trial
- Parental asthma and childhood asthma phenotypes: maternal associations with persistent asthma.BMJ open respiratory research · 2026Article
- Severe Asthma in Women: Clinical Characteristics and Pharmacological Implications for Tailored Management.Respiration; international review of thoracic diseases · 2026Article
- Lactobacillus rhamnosus regulates airway epithelial cell senescence through the ADCK5/PI3K/AKT signaling axis and alleviates airway inflammation in asthma.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Declining yet persistent asthma mortality among U.S. adults aged 65 years and older (1999-2020).Frontiers in medicine · 2026Article
- Asthma Hospitalizations in Children Before and After COVID-19: Insights from Northern Colombia.Clinics and practice · 2025Article
- Airway sympathectomy attenuates inflammation, transcriptional ratios of Muc5ac and Muc5b, and airway mechanic deficits in mice delivered intranasal IL-13.American journal of physiology. Lung cellular and molecular physiology · 2025Article
- Maternal Folic Acid Supplementation, Perinatal Factors, and Pre-Adolescent Asthma: Findings from the Healthy Growth Study.Nutrients · 2025Article
- Impact of COVID-19 pandemic on sex disparities in asthma healthcare utilisation and outcomes: a population study.ERJ open research · 2025Article
- Sex disparity in adult asthma-A potential immunomodulatory role of let-7 family microRNAs.Clinical and translational allergy · 2025Article
- Long-term trends in the burden of asthma in China: a joinpoint regression and age-period-cohort analysis based on the GBD 2021.Respiratory research · 2025Article
- Serum 17Frontiers in immunology · 2025Article
- A Multifaceted Exploration of Status Asthmaticus: A Retrospective Analysis in a Romanian Hospital.Journal of clinical medicine · 2024Article
- Comorbidities associated with adult asthma: a population-based matched cohort study in Finland.BMJ open respiratory research · 2024Article
- Study on Predicting Clinical Stage of Patients with Bronchial Asthma Based on CT Radiomics.Journal of asthma and allergy · 2024Article
- Exogenous female sex steroid hormones and new-onset asthma in women: a matched case-control study.BMC medicine · 2023Article
- The "Asthma-Polycystic Ovary Overlap Syndrome" and the Therapeutic Role of Myo-Inositol.International journal of molecular sciences · 2023Review
- New considerations of health disparities within allergy and immunology.The Journal of allergy and clinical immunology · 2023Review
- Elevated frequency and severity of asthma in patients with hiatal hernia: A retrospective study.Medicine internationalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A gender-related disparity exists in asthma morbidity and mortality, which shifts at around puberty from a male predominance to a female predominance. This is clinically reflected in the fact that asthma that occurs in childhood (childhood-onset asthma) mainly affects boys, and that asthma that occurs in adulthood (adult-onset asthma) mainly affects women. Adult-onset asthma is often non-atopic, more severe, and associated with a poorer prognosis, thus posing a marked burden to women's health and healthcare system. Many factors have been indicated to explain this gender-related disparity, including sociocultural and environmental factors as well as biological sex differences (genetic, pulmonary and immunological factors). It has long been suggested that sex hormones may be implicated in at least these biological sex differences. Overall, the evidence remains equivocal for the role of most sex hormones in asthma pathogenesis and clinical outcomes. Well-designed randomized clinical trials are required assessing the potential preventive or therapeutic effects of hormonal contraceptives on asthma in women, thereby helping to advance the evidence to inform future practice guidelines. The mechanisms underlying the role of sex hormones in asthma are complex, and our understanding is not yet complete. Additional mechanistic studies elucidating sex hormone signaling pathways and their interactions involved in the pathogenesis and clinical manifestations of asthma will help to identify potential sex hormone-driven asthma endotypes and novel therapeutic targets, providing the basis for a more personalized asthma management strategy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.