Evidence map›Paper›PMID 35210767›Full record

Trial reportInternational journal of chronic obstructive pulmonary disease

Associations with Post-Consultation Health-Status in Primary Care Managed Acute Exacerbation of COPD.

David Gillespie, Nick Francis, Haroon Ahmed, Kerenza Hood, Carl Llor, Patrick White, Emma Thomas-Jones, Helen Stanton, Bernadette Sewell, Rhiannon Phillips and 8 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in International journal of chronic obstructive pulmonary disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Exacerbations of COPD.Respiratory care · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 10 institutions in 4 countries.

David GillespieNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, England, UK.ORCID 0000-0002-6934-2928
Nick FrancisPrimary Care, Population Sciences and Medical Education, University of Southampton, Southampton, England, UK.ORCID 0000-0001-8939-7312
Haroon AhmedDivision of Population Medicine, School of Medicine, Cardiff University, Cardiff, Wales, UK.
Kerenza HoodCentre for Trials Research, School of Medicine, College of Biomedical & Life Sciences, Cardiff University, Cardiff, Wales, UK.ORCID 0000-0002-5268-8631
Carl LlorUniversity Institute in Primary Care Research Jordi Gol, Via Roma Health Centre, Barcelona, Spain.
Patrick WhiteSchool of Population Health and Environmental Sciences, Kings College London, London, England, UK.ORCID 0000-0002-2047-8787
Emma Thomas-JonesCentre for Trials Research, School of Medicine, College of Biomedical & Life Sciences, Cardiff University, Cardiff, Wales, UK.
Helen StantonCentre for Trials Research, School of Medicine, College of Biomedical & Life Sciences, Cardiff University, Cardiff, Wales, UK.
Bernadette SewellSwansea Centre for Health Economics, Swansea University, Swansea, Wales, UK.
Rhiannon PhillipsCardiff School of Sport & Health Science, Cardiff Metropolitan University, Cardiff, Wales, UK.
Gurudutt NaikDivision of Population Medicine, School of Medicine, Cardiff University, Cardiff, Wales, UK.
Hasse MelbyeGeneral Practice Research Unit, Department of Community Medicine, UIT the Arctic University of Norway, Tromsø, Norway.
Rachel LoweCentre for Trials Research, School of Medicine, College of Biomedical & Life Sciences, Cardiff University, Cardiff, Wales, UK.
Nigel KirbyCentre for Trials Research, School of Medicine, College of Biomedical & Life Sciences, Cardiff University, Cardiff, Wales, UK.
Ann CochraneYork Trials Unit, Department of Health Sciences, University of York, York, England, UK.
Janine BatesCentre for Trials Research, School of Medicine, College of Biomedical & Life Sciences, Cardiff University, Cardiff, Wales, UK.
Mohammed Fasihul AlamDepartment of Public Health, College of Health Sciences, QU-Health, Qatar University, Doha, Qatar.
Christopher ButlerNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, England, UK.ORCID 0000-0002-0102-3453
Cardiff University · GBUniversity of Oxford · GBCardiff Metropolitan University · GBInstitut Universitari d'Investigació en Atenció Primària Jordi Gol · ESKing's College London · GBQatar University · QASwansea University · GBUiT The Arctic University of Norway · NOUniversity of Southampton · GBUniversity of York · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt has been demonstrated that antibiotic prescribing for Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) can be safely reduced in primary care when general practitioners have access to C-reactive protein (CRP) rapid testing.

aimTo investigate the factors associated with post-consultation COPD health status in patients presenting with AECOPD in this setting. DESIGN AND

settingA cohort study of patients enrolled in a randomised controlled trial. Patients aged 40+ years with a clinical diagnosis of COPD who presented in primary care across England and Wales with an AECOPD were included.

methodsParticipants were contacted for follow-up at one- and two-weeks by phone and attended the practice four weeks after the index consultation. The outcome of interest was the Clinical COPD Questionnaire (CCQ) score. Multivariable multilevel linear regression models fitted to examine the factors associated with COPD health status in the four-weeks following consultation for an AECOPD.

resultsA total of 649 patients were included, with 1947 CCQ total scores analysed. Post-consultation CCQ total scores were significantly higher (worse) in participants with diabetes (adjusted mean difference [AMD]=0.26; 95% confidence interval (CI) 0.08-0.45), obese patients compared to those with normal body mass index (AMD = 0.25, 95% CI 0.07-0.43), and those who were prescribed oral antibiotics in the prior 12 months (AMD = 0.26; 95% CI 0.11-0.41), but only the two latter associations remained after adjusting for other sociodemographic variables.

conclusionCOPD health status was worse in the four weeks following primary care consultation for AECOPD in patients with obesity and those prescribed oral antibiotics in the preceding year.

Indexed as

Pulmonary Disease, Chronic ObstructiveAdultCohort StudiesDisease ProgressionHealth StatusHumansPrimary Health CareReferral and Consultationchronic obstructivehealth statusPrimary Health Carepulmonary diseasesymptom exacerbation

Identifiers

PMID35210767
PMCPMC8859472
OpenAlexW4212829521

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.