Evidence map›Paper›PMID 35210625›Full record

SynthesisNature genetics2022

Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility.

Julien Barc, Rafik Tadros, Charlotte Glinge, David Y Chiang, Mariam Jouni, Floriane Simonet, Sean J Jurgens, Manon Baudic, Michele Nicastro, Franck Potet and 138 more

Erratum issuedOpen access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 83 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 5 pooled it
21.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 5 syntheses or guidelines pooled it, 140 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. The SCN5A Gene Is a Predictor of Phenotype Severity in Brugada Syndrome: A Comprehensive Literature Review.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2023
    Pooled it
  6. Article
  7. Article
  8. Brugada Syndrome: an exemplar for the genomic basis of sudden death.European journal of human genetics : EJHG · 2026
    Review
  9. Review
  10. Genome-wide association study-identified novel genetic loci for QT interval in Taiwan: implications for population-specific arrhythmia risk.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  11. Further mystification of SCN5A phenotypes: sodium channel blockade in individuals with loss-of-function sodium channel mutations dangerous or helpful?Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Phenotypic expression of rare progressive cardiac conduction disease variants in the general population.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  19. Cardiac arrhythmias and genetics - current stage.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2025
    Article
  20. Brugada syndrome.Nature reviews. Disease primers · 2025
    Review

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

148 authors at 20 institutions in 12 countries.

Julien Barc *Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France. julien.barc@univ-nantes.fr.ORCID http://orcid.org/0000-0003-4106-5946
Rafik Tadros *Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-1472-0258
Charlotte Glinge *Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
David Y Chiang *Medicine, Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5883-6383
Mariam Jouni *Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Floriane Simonet *Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
Sean J JurgensThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1605-9782
Manon BaudicUniversité de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
Michele NicastroDepartment of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-4136-2599
Franck PotetDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Joost A OfferhausDepartment of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Roddy WalshDepartment of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-5092-8825
Seung Hoan ChoiThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-2797-3190
Arie O VerkerkDepartment of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-2140-834X
Yuka MizusawaEuropean Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Soraya AnysUniversité de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
Damien MinoisUniversité de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
Marine ArnaudUniversité de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
Josselin DuchateauIHU Liryc, Electrophysiology and Heart Modeling Institute, fondation Bordeaux Université, Pessac-Bordeaux, France.
Yanushi D WijeyeratneEuropean Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Alison MuirCardiology, Belfast Health and Social Care Trust and Queen's University Belfast, Belfast, UK.
Michael PapadakisMolecular and Clinical Sciences Research Institute, St. George's, University of London, London, UK.
Silvia CastellettiCenter for Cardiac Arrhythmias of Genetic Origin, Istituto Auxologico Italiano IRCCS, Milan, Italy.
Margherita TorchioLaboratory of Cardiovascular Genetics, Istituto Auxologico Italiano IRCCS, Cusano Milanino, Italy.
Cristina Gil OrtuñoCardiogenetic, Unidad de Cardiopatías Familiares, Instituto Murciano de Investigación Biosanitaria, Universidad de Murcia, Murcia, Spain.ORCID http://orcid.org/0000-0001-7296-3445
Javier LacunzaCardiology, Unidad de Cardiopatías Familiares, Hospital Universitario Virgen de la Arrixaca, Universidad de Murcia, Murcia, Spain.
Daniela F GiachinoClinical and Biological Sciences, Medical Genetics, University of Torino, Orbassano, Italy.ORCID http://orcid.org/0000-0002-3186-6726
Natascia CerratoMedical Sciences, Cardiology, University of Torino, Torino, Italy.
Raphaël P MartinsCardiologie et Maladies vasculaires, Université Rennes1 - CHU Rennes, Rennes, France.
Oscar CampuzanoCardiovascular Genetics Center, University of Girona-IDIBGI, Girona, Spain.ORCID http://orcid.org/0000-0001-5298-5276
Sonia Van DoorenEuropean Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Aurélie TholletUniversité de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
Florence KyndtUniversité de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
Andrea MazzantiEuropean Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Nicolas ClémentyDepartment of Cardiology, CHU Tours, Tours, France.
Arnaud BissonDepartment of Cardiology, CHU Tours, Tours, France.ORCID http://orcid.org/0000-0002-3449-1800
Anniek CorveleynDepartment of Human Genetics, Catholic University Leuven, Leuven, Belgium.
Birgit StallmeyerUniversity Hospital Münster, Institute for Genetics of Heart Diseases (IfGH), Münster, Germany.
Sven DittmannUniversity Hospital Münster, Institute for Genetics of Heart Diseases (IfGH), Münster, Germany.
Johan SaenenCardiology, Electrophysiology - Cardiogenetics, University of Antwerp/Antwerp University Hospital, Edegem, Belgium.
Antoine NoëlDepartment of Cardiology, University Hospital of Brest, Brest, France.
Shohreh HonarbakhshCardiology, Medicine, Barts Heart Centre, London, UK.
Boris RudicDepartment 1st of Medicine, Cardiology, University Medical Center Mannheim, Mannheim, Germany.
Halim MarzakDepartment of Cardiology, University Hospital of Strasbourg, Strasbourg, France.
Matthew K RoweMedicine, Cardiology, Western University, London, Ontario, Canada.
Claire FederspielDepartment of Cardiovascular Medicine, Vendée Hospital, Service de Cardiologie, La Roche sur Yon, France.
Sophie Le PageService de cardiologie, CHU Angers, Angers, France.
Leslie PlacideDepartment of Cardiology, CHU Montpellier, Montpellier, France.
Antoine MilhemDepartment of Cardiology, CH La Rochelle, La Rochelle, France.
Hector Barajas-MartinezLankenau Institute for Medical Research, Wynnewood, PA, USA.ORCID http://orcid.org/0000-0002-2704-3807
Britt-Maria BeckmannDepartment of Medicine I, University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0003-4176-4050
Ingrid P KrapelsDepartment of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.
Johannes SteinfurtDepartment of Cardiology and Angiology I, Heart Center, University Freiburg, Freiburg, Germany.
Bo Gregers WinkelEuropean Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Reza JabbariEuropean Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Moore B ShoemakerMedicine, Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Bas J BoukensDepartment of Medical Biology, University of Amsterdam, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Doris Škorić-MilosavljevićDepartment of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Hennie BikkerEuropean Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Federico ManevyDepartment of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Peter LichtnerInstitute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany.
Marta RibasésPsychiatric Genetics Unit, Institute Vall d'Hebron Research (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Thomas MeitingerInstitute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany.
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.ORCID http://orcid.org/0000-0003-3793-5910
KORA-Study Group
Jan H VeldinkDepartment of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0001-5572-9657
Leonard H van den BergDepartment of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Philip Van DammeNeurology Department University Hospital Leuven, Neuroscience Department KU Leuven, Center for Brain & Disease Research VIB, Leuven, Belgium.ORCID http://orcid.org/0000-0002-4010-2357
Daniele CusiScientific Unit, Bio4Dreams - Business Nursery for Life Sciences, Milan, Italy.
Chiara LanzaniNephrology, Genomics of Renal Diseases and Hypertension Unit, Università Vita Salute San Raffaele, Milan, Italy.
Sidwell RigadeUniversité de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
Eric CharpentierUniversité de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
Estelle BaronUniversité de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.ORCID http://orcid.org/0000-0002-5509-3086
Stéphanie BonnaudUniversité de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
Simon LecointeUniversité de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.ORCID http://orcid.org/0000-0002-1785-7735
Audrey DonnartUniversité de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
Hervé Le MarecUniversité de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
Stéphanie ChatelUniversité de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
Matilde KarakachoffUniversité de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
Stéphane BézieauUniversité de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.ORCID http://orcid.org/0000-0003-0095-1319
Barry LondonDepartment of Internal Medicine, Division of Cardiovascular Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Jacob Tfelt-HansenEuropean Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Dan RodenMedicine, Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.
Katja E OdeningDepartment of Cardiology and Angiology I, Heart Center, University Freiburg, Freiburg, Germany.
Marina CerroneMedicine, Leon H. Charney Division of Cardiology, Heart Rhythm Center and Cardiovascular Genetics Program, New York University School of Medicine, New York, NY, USA.
Larry A ChinitzMedicine, Leon H. Charney Division of Cardiology, Heart Rhythm Center and Cardiovascular Genetics Program, New York University School of Medicine, New York, NY, USA.
Paul G VoldersDepartment of Cardiology, CARIM, Maastricht University Medical Center, Maastricht, The Netherlands.
Maarten P van de BergDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-1493-2998
Gabriel LaurentCardiology Department, ImVia lab team IFTIM, University Hospital Dijon, Dijon, France.
Laurence FaivreCentre de Génétique, FHU TRANSLAD, Dijon, France.
Charles AntzelevitchLankenau Institute for Medical Research, Wynnewood, PA, USA.
Stefan KääbEuropean Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Alain Al ArnaoutDepartment of Cardiology, CH La Rochelle, La Rochelle, France.
Jean-Marc DupuisService de cardiologie, CHU Angers, Angers, France.
Jean-Luc PasquieDepartment of Cardiology, CNRS UMR9214 - Inserm U1046 - PHYMEDEXP, Université de Montpellier et CHU Montpellier, Montpellier, France.
Olivier BillonDepartment of Cardiovascular Medicine, Vendée Hospital, Service de Cardiologie, La Roche sur Yon, France.
Jason D RobertsMedicine, Cardiology, Western University, London, Ontario, Canada.
Laurence JeselDepartment of Cardiology, University Hospital of Strasbourg, Strasbourg, France.
Martin BorggrefeDepartment 1st of Medicine, Cardiology, University Medical Center Mannheim, Mannheim, Germany.
Pier D LambiaseCardiology, Medicine, Barts Heart Centre, London, UK.
Jacques MansouratiDepartment of Cardiology, University Hospital of Brest, Brest, France.
Bart LoeysCenter for Medical Genetics, Cardiogenetics, University of Antwerp/Antwerp University Hospital, Edegem, Belgium.
Antoine LeenhardtEuropean Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Pascale GuicheneySorbonne Université, Paris, France.
Philippe MauryService de cardiologie, Hôpital Rangueil, CHU de Toulouse, Toulouse, France.
Eric Schulze-BahrEuropean Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Tomas RobynsEuropean Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Jeroen BreckpotEuropean Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.ORCID http://orcid.org/0000-0002-0734-5154
Dominique BabutyDepartment of Cardiology, CHU Tours, Tours, France.
Silvia G PrioriEuropean Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Carlo NapolitanoEuropean Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.ORCID http://orcid.org/0000-0002-7643-4628
Nantes Referral Center for inherited cardiac arrhythmia
Carlo de AsmundisEuropean Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.ORCID http://orcid.org/0000-0001-9351-0760
Pedro BrugadaHeart Rhythm Management Center, UZ Brussel-VUB, Brussels, Belgium.
Ramon BrugadaHospital Trueta, CiberCV, University of Girona, IDIBGI, Girona, Spain, Barcelona, Spain.
Elena ArbeloArrhythmia Section, Cardiology Department, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0003-0424-6393
Josep BrugadaCardiovascular Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.
Philippe MaboCardiologie et Maladies vasculaires, Université Rennes1 - CHU Rennes, Rennes, France.
Nathalie BeharCardiologie et Maladies vasculaires, Université Rennes1 - CHU Rennes, Rennes, France.
Carla GiustettoMedical Sciences, Cardiology, University of Torino, Torino, Italy.
Maria Sabater MolinaCardiogenetic, Unidad de Cardiopatías Familiares, Instituto Murciano de Investigación Biosanitaria, Universidad de Murcia, Murcia, Spain.ORCID http://orcid.org/0000-0003-1352-1748
Juan R GimenoEuropean Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Can HasdemirDepartment of Cardiology, Ege University School of Medicine, Bornova, Turkey.
Peter J SchwartzEuropean Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.ORCID http://orcid.org/0000-0003-0367-1048
Lia CrottiEuropean Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Pascal P McKeownCardiology, Belfast Health and Social Care Trust and Queen's University Belfast, Belfast, UK.ORCID http://orcid.org/0000-0001-7488-3094
Sanjay SharmaMolecular and Clinical Sciences Research Institute, St. George's, University of London, London, UK.
Elijah R BehrEuropean Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.ORCID http://orcid.org/0000-0002-8731-2853
Michel HaissaguerreIHU Liryc, Electrophysiology and Heart Modeling Institute, fondation Bordeaux Université, Pessac-Bordeaux, France.
Frédéric SacherIHU Liryc, Electrophysiology and Heart Modeling Institute, fondation Bordeaux Université, Pessac-Bordeaux, France.
Caroline RooryckCHU Bordeaux, Service de Génétique Médicale, Bordeaux, France.
Hanno L TanDepartment of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Carol A RemmeDepartment of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Pieter G PostemaEuropean Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Mario DelmarMedicine, Cardiology, New York University School of Medicine, New York, NY, USA.
Patrick T EllinorCardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital and Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2067-0533
Steven A LubitzCardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital and Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9599-4866
Jean-Baptiste GourraudUniversité de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
Michael W TanckClinical Epidemiology, Biostatistics and Bioinformatics, Clinical Methods and Public Health, Amsterdam Public Health, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-9828-4459
Alfred L GeorgeDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-3993-966X
Calum A MacRaeMedicine, Cardiovascular Medicine, Genetics and Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Paul W BurridgeDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-9616-0006
Christian DinaUniversité de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.ORCID http://orcid.org/0000-0002-7722-7348
Vincent Probst *Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
Arthur A Wilde *European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Jean-Jacques Schott *Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.ORCID http://orcid.org/0000-0002-9578-9475
Richard Redon *Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.ORCID http://orcid.org/0000-0001-7751-2280
Connie R Bezzina *European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart, . c.r.bezzina@amsterdamumc.nl.ORCID http://orcid.org/0000-0002-0633-3514
Centre National de la Recherche Scientifique · FRAmsterdam Neuroscience · NLHelmholtz Zentrum München · DENorthwestern University · USBroad Institute · USCentre Hospitalier Universitaire de Rennes · FRInserm · FRSt George's, University of London · GBUniversity of Pavia · ITCentre Hospitalier Universitaire de Tours · FRCopenhagen University Hospital · DKInstituto Murciano de Investigación Biosanitaria · ESIRCCS Istituto Auxologico Italiano · ITLankenau Institute for Medical Research · USQueen's University Belfast · GBUniversitat de Girona · ESUniversity Hospital Münster · DEUniversity of Antwerp · BEUniversity of Freiburg · DEUtrecht University · NL

Funding

IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6M
Understanding and preventing HLA-associated drug reactionsP50GM115305 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DENNY, JOSHUA C. · 2015 to 2019
$13.0M
ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIASR01HL047678 · NHLBI · MASONIC MEDICAL RESEARCH LABORATORY, INC · PI ANTZELEVITCH, CHARLES · 1993 to 2014
$5.7M
Genomics of Cardiac ArrhythmiasR01HL139731 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS · 2018 to 2022
$3.3M
Partners Healthcare Training Program in Precision and Genomic MedicineT32HG010464 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI HEIDI L REHM, JORDAN W SMOLLER · 2019 to 2026
$3.1M
AFGen Consortium: Atrial Fibrillation Genomics to Functional AnalysesR01HL128914 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2015 to 2018
$3.1M
Functional Genomics of Cardiac Sodium Channel VariantsR01HL149826 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RODEN, DAN M · 2020 to 2023
$2.9M
Role of desmosomes in cardiac electrical functionR01HL134328 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DELMAR, MARIO, MORLEY, GREGORY E · 2016 to 2019
$2.6M
Development of a whole heart model of the J wave syndromes and novel approaches to pharmacologic management of associated life-threatening arrhythmiasR01HL152201 · NHLBI · LANKENAU INSTITUTE FOR MEDICAL RESEARCH · PI ANTZELEVITCH, CHARLES, DI DIEGO, JOSE M. · 2020 to 2023
$2.5M
Mentoring in Arrhythmia ResearchK24HL105780 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS · 2011 to 2020
$1.2M
Atrial Fibrillation Susceptibility Due to Genetic Variation at Chromosome 4q25K23HL127704 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHOEMAKER, MOORE BENJAMIN · 2015 to 2019
$869k
Novel Approaches to Pharmacologic Management of Life-Threatening Arrhythmias Associated with the J Wave SyndromesR56HL138103 · NHLBI · LANKENAU INSTITUTE FOR MEDICAL RESEARCH · PI ANTZELEVITCH, CHARLES · 2018 to 2018
$413k
British Heart Foundation FS/11/71/28918NHGRI NIH HHS T32 HG010464NHLBI NIH HHS K23 HL127704NHLBI NIH HHS K24 HL105780NHLBI NIH HHS R01 HL047678NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL128914NHLBI NIH HHS R01 HL134328NHLBI NIH HHS R01 HL139731NHLBI NIH HHS R01 HL149826NHLBI NIH HHS R01 HL152201NHLBI NIH HHS R56 HL138103NIGMS NIH HHS P50 GM115305Wellcome TrustWellcome Trust 076113Wellcome Trust 085475Wellcome Trust 090355
6 · The paper itself

Abstract

Brugada syndrome (BrS) is a cardiac arrhythmia disorder associated with sudden death in young adults. With the exception of SCN5A, encoding the cardiac sodium channel Na

Indexed as

Brugada SyndromeAllelesDisease SusceptibilityGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMicrotubule-Associated ProteinsMutationNAV1.5 Voltage-Gated Sodium ChannelYoung AdultMAPRE2 protein, humanMicrotubule-Associated ProteinsNAV1.5 Voltage-Gated Sodium Channel

Identifiers

PMID35210625
PMCPMC9376964
OpenAlexW4213416315

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