ArticleNature ecology & evolution2022
Domestication reprogrammed the budding yeast life cycle.
Article in Nature ecology & evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 79 citations in OpenAlex.
- Article
- Genotypic and Phenotypic Diversity of Maudiozyma humilis: The Multiple Evolutionary Trajectories of a Domesticated Yeast.Genome biology and evolution · 2026Article
- From Oak to Wine: Evolution, Admixture, and Adaptation of California and British Columbia Saccharomyces Cerevisiae Wine Strains.Genome biology and evolution · 2026Article
- Distinctive domestication of farmhouse beer yeasts preserved pre-industrial genetic and phenotypic diversity.Current biology : CB · 2026Article
- Seven draft genomes ofMicrobiology resource announcements · 2026Article
- Influence of Ploidy and Genetic Background on Stress Tolerance of Intraspecific Yeast Hybrids.Microbial biotechnology · 2026Article
- Recurrent introgression and geographical stratification shape Saccharomyces cerevisiae in the Neotropics.Nature communications · 2026Article
- Domestication drives repeated evolution of sexual-asexual life cycle trade-offs in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Repeated losses of self-fertility shaped heterozygosity and polyploidy in yeast evolution.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- From one genome to thousands, and beyond.FEMS yeast research · 2026Review
- Genomic adaptation of an autochthonous cider yeast strain to buckwheat and barley wort under stressful brewing conditions.Applied and environmental microbiology · 2025Article
- Predicting natural variation in the yeast phenotypic landscape with machine learning.Molecular systems biology · 2025Article
- Impacts of temperature on recombination rate and meiotic success in thermotolerant and cold-tolerant yeast species.Heredity · 2025Article
- High-Throughput Indirect Monitoring of TORC1 Activation Using the pTOMAN-G Plasmid in Yeast.Bio-protocol · 2025Article
- Article
- The dynamics of loss of heterozygosity events in genomes.EMBO reports · 2025Review
- Wild yeast isolation by middle-school students reveals features of populations residing on North American oaks.G3 (Bethesda, Md.) · 2025Article
- ScRAPdb: an integrated pan-omics database for the Saccharomyces cerevisiae reference assembly panel.Nucleic acids research · 2025Article
- Phenotyping of a new yeast mapping population reveals differences in the activation of the TORC1 signalling pathway between wild and domesticated yeast strains.Biological research · 2024Article
- Life history in Caenorhabditis elegans: from molecular genetics to evolutionary ecology.Genetics · 2024Review
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Domestication of plants and animals is the foundation for feeding the world human population but can profoundly alter the biology of the domesticated species. Here we investigated the effect of domestication on one of our prime model organisms, the yeast Saccharomyces cerevisiae, at a species-wide level. We tracked the capacity for sexual and asexual reproduction and the chronological life span across a global collection of 1,011 genome-sequenced yeast isolates and found a remarkable dichotomy between domesticated and wild strains. Domestication had systematically enhanced fermentative and reduced respiratory asexual growth, altered the tolerance to many stresses and abolished or impaired the sexual life cycle. The chronological life span remained largely unaffected by domestication and was instead dictated by clade-specific evolution. We traced the genetic origins of the yeast domestication syndrome using genome-wide association analysis and genetic engineering and disclosed causative effects of aneuploidy, gene presence/absence variations, copy number variations and single-nucleotide polymorphisms. Overall, we propose domestication to be the most dramatic event in budding yeast evolution, raising questions about how much domestication has distorted our understanding of the natural biology of this key model species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.