Evidence map›Paper›PMID 35210395›Full record

ArticleBlood cancer journal2022

Black patients with multiple myeloma have better survival than white patients when treated equally: a matched cohort study.

Jing Dong, Zhuping Garacci, Christopher Staffi Buradagunta, Anita D'Souza, Meera Mohan, Ashley Cunningham, Siegfried Janz, Binod Dhakal, Aaron P Thrift, Parameswaran Hari

Open access · goldAbstract read
In one paragraph

Article in Blood cancer journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
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  18. Disparities in Musculoskeletal Oncology.Current reviews in musculoskeletal medicine · 2024
    Review
  19. Diversity, Equity, and Inclusion in Multiple Myeloma: A Call to Action.Journal of the advanced practitioner in oncology · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jing DongDivision of Hematology Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA. jidong@mcw.edu.ORCID 0000-0001-9856-5963
Zhuping GaracciCenter for Advancing Population Science, Medical College of Wisconsin, Milwaukee, WI, USA.
Christopher Staffi BuradaguntaDivision of Hematology Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Anita D'SouzaDivision of Hematology Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0002-1092-5643
Meera MohanDivision of Hematology Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0002-6913-6526
Ashley CunninghamDepartment of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA.
Siegfried JanzDivision of Hematology Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0002-2229-5511
Binod DhakalDivision of Hematology Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0002-4377-9742
Aaron P ThriftSection of Epidemiology and Population Sciences, Department of Medicine, and Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Parameswaran HariDivision of Hematology Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0002-8800-297X
Medical College of Wisconsin · USBaylor College of Medicine · US

Funding

CALIFORNIA COORDINATED CANCER PREVENTION & CONTROL PROGRAMU58DP003862 · DP · CALIFORNIA STATE DEPT OF PUBLIC HEALTH · PI SNIPES, KURT P · 2012 to 2014
$31.5M
Defining genetic pathways of plasma-cell neoplasiaR01CA151354 · NCI · UNIVERSITY OF IOWA · PI JANZ, SIEGFRIED · 2010 to 2022
$3.9M
NCCDPHP CDC HHS U58 DP003862NCI NIH HHS HHSN261201000034CNCI NIH HHS HHSN261201000035CNCI NIH HHS HHSN261201000035INCI NIH HHS HHSN261201000140CNCI NIH HHS R01 CA151354
6 · The paper itself

Abstract

We assessed differences in survival between non-Hispanic black (NHB) and non-Hispanic white (NHW) patients with multiple myeloma (MM), and the sequential effects of patient characteristics, and diagnosis and treatment-related factors on the survival disparity using data from 3319 NHB and 20,831 NHW MM patients in the SEER-Medicare (1999-2017) database. Four sets of 3319 NHWs were matched sequentially to the same set of 3319 NHBs, based on demographics (age, sex, year of diagnosis, marital status, and SEER site), socioeconomic status (SES, demographics plus SES), presentation factors (SES variables plus comorbidity), and treatment factors (presentation variables plus antimyeloma therapies). We found NHBs were less likely to receive treatment than NHWs even among patients matched for demographics, SES, and comorbidities. The absolute difference in 5-year survival between NHBs and NHWs was not significant in the demographics match (0.6%; P = 0.30) and remained non-significant after matching for SES (1.4%, P = 0.17). When matching for presentation, NHBs had significantly longer 5-year survival than NHWs (absolute difference = 3.8%, P = 0.003). Additional matching on treatment-related factors further enlarged the racial difference in 5-year survival to 4.6% (P < 0.001). Our findings reinforce the importance of equitable access to effective treatment modalities to further improve the survival of NHB patients with MM.

Indexed as

Multiple MyelomaAgedBlack or African AmericanBlack PeopleCohort StudiesHumansMedicareUnited StatesWhite People

Identifiers

PMID35210395
PMCPMC8873507
OpenAlexW4213456270

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.