ArticleBMJ open2022
Bedtime versus morning use of antihypertensives for cardiovascular risk reduction (BedMed): protocol for a prospective, randomised, open-label, blinded end-point pragmatic trial.
Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02990663 (The Effect of Antihypertensive Medication Timing on Morbidity and Mortality), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Antihypertensive Medication Timing on Morbidity and Mortality: The "BedMed" RCT
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- A Review of Clinical Trial and Meta-Analyses of BP Treatment Strategies for Patients with Orthostatic Hypotension: Blood Pressure Management in Patients with Hypertension and Orthostatic Hypotension.Current hypertension reports · 2026Pooled it
- Bedtime vs Morning Antihypertensive Medications in Frail Older Adults: The BedMed-Frail Randomized Clinical Trial.JAMA network open · 2025Trial
- Trial
- Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial.Lancet (London, England) · 2022Trial
- The Effect of Chronotherapy on Clinical Outcomes in Hypertensive Patients: A Systematic Review and Meta-Analysis Comparing Bedtime Versus Morning Dosing of Antihypertensive Drugs.Health science reports · 2026Review
- The Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025).Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Supine hypertension and cardiovascular disease: controversies and advances.Future cardiology · 2025Review
- Interaction Between Chronotype and the Timing of Antihypertensive Medication on Cardiovascular Events and Death.Journal of the American Heart Association · 2025Article
- Advances in Clinical Cardiology 2024: A Summary of Key Clinical Trials.Advances in therapy · 2025Review
- Does the timing of blood pressure medication really matter?International journal of cardiology. Cardiovascular risk and prevention · 2024Article
- Nighttime administration of antihypertensive medication: a review of chronotherapy in hypertension.The Korean journal of internal medicine · 2024Review
- Pressure Building Against the Clock: The Impact of Circadian Misalignment on Blood Pressure.Current hypertension reports · 2024Review
- Non-Dipping Blood Pressure or Nocturnal Hypertension: Does One Matter More?Current hypertension reports · 2024Review
- Statement on chronotherapy for the treatment of hypertension: consensus document from the Korean society of hypertension.Clinical hypertension · 2023Review
- Article
- Top studies of 2022 relevant to primary care: From the PEER team.Canadian family physician Medecin de famille canadien · 2023Review
- Blood pressure in heart failure management and prevention.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Review
- Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension - 2021 NHLBI Workshop Report.Hypertension (Dallas, Tex. : 1979) · 2023Review
- Improper administration: Silent culprit of drug therapy problems.Canadian family physician Medecin de famille canadien · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 9 institutions in 1 country.
Funding
Abstract
introductionSleep-time blood pressure correlates more strongly with adverse cardiovascular events than does daytime blood pressure. The BedMed trial evaluates whether bedtime antihypertensive administration, as compared with conventional morning use, reduces major adverse cardiovascular events. METHODS AND ANALYSIS: ETHICS AND DISSEMINATION: BedMed has ethics approval from six research ethics review boards and will publish results in a peer-reviewed journal. TRIAL REGISTRATION NUMBER: NCT02990663.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.