Evidence map›Paper›PMID 35210336›Full record

ArticleBMJ open2022

Side effects of COVID-19 vaccines: a systematic review and meta-analysis protocol of randomised trials.

Kleyton Santos Medeiros, Ana Paula Ferreira Costa, Ayane Cristine Alves Sarmento, Cijara Leonice Freitas, Ana Katherine Gonçalves

Abstract read
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Safety and efficiency of COVID-19 vaccine in North Africa.Human vaccines & immunotherapeutics · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
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  11. Article
  12. Article
  13. Exploring the volatile metabolites of threeSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
    Article
  14. Impact of COVID-19 Preventative Measures on Otolaryngology in Taiwan: A Nationwide Study.International journal of environmental research and public health · 2023
    Article
  15. Article
  16. Article
  17. Article
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  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kleyton Santos MedeirosHealth Sciences Postgraduate Program, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Ana Paula Ferreira CostaHealth Sciences Postgraduate Program, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Ayane Cristine Alves SarmentoHealth Sciences Postgraduate Program, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Cijara Leonice FreitasHealth Sciences Postgraduate Program, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Ana Katherine GonçalvesDepartment of Obstetrics and Gynecology, Universidade Federal do Rio Grande do Norte, Natal, Brazil anakatherine_ufrnet@yahoo.com.br.ORCID 0000-0002-8351-5119

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSARS-CoV-2 is responsible for a large number of global COVID-19 cases. Strategies such as social isolation, personal hygiene and frequent hand washing have been implemented; however, a protective vaccine is required to achieve sufficient herd immunity to SARS-CoV-2 infection to ultimately control the COVID-19 pandemic. To meet the urgent need for a vaccine, a reduction in the development schedule has been proposed from 10-15 years to 1-2 years. For this reason, this systematic review and meta-analysis protocol aims to compare the side effects, safety and toxicity of COVID-19 vaccines available globally, including their combinations. METHODS AND ANALYSIS: We will select randomised controlled trial-type studies that evaluate the side effects of the COVID-19 vaccine. PubMed, Web of Science, Embase, CINAHL, PsycINFO, LILACS, SCOPUS, ClinicalTrials.gov, International Clinical Trials Registry Platform (ICTRP), medRxiv.org, biorxiv.org, preprints.org and the Cochrane Library will be searched for eligible studies until December 2021. Three reviewers will independently screen and select studies, assess methodological quality and extract data. A meta-analysis will be performed, if possible, and the Grading of Recommendations, Assessment, Development and Evaluations summary of findings will be presented. ETHICS AND DISSEMINATION: This study will review published data, and thus it is unnecessary to obtain ethical approval. The findings of this systematic review will be published in a peer-reviewed journal. PROSPERO REGISTRATION NUMBER: CRD42021231101.

Indexed as

COVID-19COVID-19 VaccinesHumansMeta-Analysis as TopicPandemicsRandomized Controlled Trials as TopicResearch DesignSARS-CoV-2Social IsolationSystematic Reviews as TopicCOVID-19 Vaccinesadverse eventsclinical trialsCOVID-19immunologytoxicology

Identifiers

PMID35210336
PMCPMC8882642

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.