Evidence map›Paper›PMID 35210294›Full record

ArticleNeurology2022

Cerebrovascular Reactivity Across the Entire Brain in Cerebral Amyloid Angiopathy.

Andrew E Beaudin, Cheryl R McCreary, Erin L Mazerolle, Myrlene Gee, Breni Sharma, Arsenije Subotic, Angela M Zwiers, Emily Cox, Krista Nelles, Anna Charlton and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Observational
  6. Article
  7. Plasma biomarkers distinguish Boston Criteria 2.0 cerebral amyloid angiopathy from healthy controls.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  8. Observational
  9. Observational
  10. Article
  11. Article
  12. Article
  13. Article
  14. Cerebral amyloid angiopathy and the immune system.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Review
  15. Article
  16. Neurovascular coupling in early stage dementia - A case-control study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  17. Observational
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Andrew E BeaudinFrom the Department of Clinical Neurosciences (A.E.B., C.R.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Hotchkiss Brain Institute (A.E.B., C.R.M., E.L.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Department of Radiology (C.R.M., E.L.M., R.F., G.B.P., E.E.S.), Department of Psychiatry (Z.I.), and Mathison Centre for Mental Health Research & Education (Z.I.), University of Calgary; Seaman Family MR Research Centre, Foothills Medical Centre (C.R.M., R.F., G.B.P., E.E.S.), Alberta Health Services, Calgary; Department of Psychology (E.L.M.), St. Francis Xavier University, Antigonish; and Division of Neurology and Department of Medicine (M.G., K.N., G.C.J., R.C.), Department of Biomedical Engineering (C.B.), and Neuroscience and Mental Health Institute (R.C.), University of Alberta, Edmonton, Canada.ORCID 0000-0002-3295-7232
Cheryl R McCrearyFrom the Department of Clinical Neurosciences (A.E.B., C.R.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Hotchkiss Brain Institute (A.E.B., C.R.M., E.L.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Department of Radiology (C.R.M., E.L.M., R.F., G.B.P., E.E.S.), Department of Psychiatry (Z.I.), and Mathison Centre for Mental Health Research & Education (Z.I.), University of Calgary; Seaman Family MR Research Centre, Foothills Medical Centre (C.R.M., R.F., G.B.P., E.E.S.), Alberta Health Services, Calgary; Department of Psychology (E.L.M.), St. Francis Xavier University, Antigonish; and Division of Neurology and Department of Medicine (M.G., K.N., G.C.J., R.C.), Department of Biomedical Engineering (C.B.), and Neuroscience and Mental Health Institute (R.C.), University of Alberta, Edmonton, Canada.
Erin L MazerolleFrom the Department of Clinical Neurosciences (A.E.B., C.R.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Hotchkiss Brain Institute (A.E.B., C.R.M., E.L.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Department of Radiology (C.R.M., E.L.M., R.F., G.B.P., E.E.S.), Department of Psychiatry (Z.I.), and Mathison Centre for Mental Health Research & Education (Z.I.), University of Calgary; Seaman Family MR Research Centre, Foothills Medical Centre (C.R.M., R.F., G.B.P., E.E.S.), Alberta Health Services, Calgary; Department of Psychology (E.L.M.), St. Francis Xavier University, Antigonish; and Division of Neurology and Department of Medicine (M.G., K.N., G.C.J., R.C.), Department of Biomedical Engineering (C.B.), and Neuroscience and Mental Health Institute (R.C.), University of Alberta, Edmonton, Canada.
Myrlene GeeFrom the Department of Clinical Neurosciences (A.E.B., C.R.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Hotchkiss Brain Institute (A.E.B., C.R.M., E.L.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Department of Radiology (C.R.M., E.L.M., R.F., G.B.P., E.E.S.), Department of Psychiatry (Z.I.), and Mathison Centre for Mental Health Research & Education (Z.I.), University of Calgary; Seaman Family MR Research Centre, Foothills Medical Centre (C.R.M., R.F., G.B.P., E.E.S.), Alberta Health Services, Calgary; Department of Psychology (E.L.M.), St. Francis Xavier University, Antigonish; and Division of Neurology and Department of Medicine (M.G., K.N., G.C.J., R.C.), Department of Biomedical Engineering (C.B.), and Neuroscience and Mental Health Institute (R.C.), University of Alberta, Edmonton, Canada.
Breni SharmaFrom the Department of Clinical Neurosciences (A.E.B., C.R.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Hotchkiss Brain Institute (A.E.B., C.R.M., E.L.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Department of Radiology (C.R.M., E.L.M., R.F., G.B.P., E.E.S.), Department of Psychiatry (Z.I.), and Mathison Centre for Mental Health Research & Education (Z.I.), University of Calgary; Seaman Family MR Research Centre, Foothills Medical Centre (C.R.M., R.F., G.B.P., E.E.S.), Alberta Health Services, Calgary; Department of Psychology (E.L.M.), St. Francis Xavier University, Antigonish; and Division of Neurology and Department of Medicine (M.G., K.N., G.C.J., R.C.), Department of Biomedical Engineering (C.B.), and Neuroscience and Mental Health Institute (R.C.), University of Alberta, Edmonton, Canada.ORCID 0000-0001-8560-9664
Arsenije SuboticFrom the Department of Clinical Neurosciences (A.E.B., C.R.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Hotchkiss Brain Institute (A.E.B., C.R.M., E.L.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Department of Radiology (C.R.M., E.L.M., R.F., G.B.P., E.E.S.), Department of Psychiatry (Z.I.), and Mathison Centre for Mental Health Research & Education (Z.I.), University of Calgary; Seaman Family MR Research Centre, Foothills Medical Centre (C.R.M., R.F., G.B.P., E.E.S.), Alberta Health Services, Calgary; Department of Psychology (E.L.M.), St. Francis Xavier University, Antigonish; and Division of Neurology and Department of Medicine (M.G., K.N., G.C.J., R.C.), Department of Biomedical Engineering (C.B.), and Neuroscience and Mental Health Institute (R.C.), University of Alberta, Edmonton, Canada.
Angela M ZwiersFrom the Department of Clinical Neurosciences (A.E.B., C.R.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Hotchkiss Brain Institute (A.E.B., C.R.M., E.L.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Department of Radiology (C.R.M., E.L.M., R.F., G.B.P., E.E.S.), Department of Psychiatry (Z.I.), and Mathison Centre for Mental Health Research & Education (Z.I.), University of Calgary; Seaman Family MR Research Centre, Foothills Medical Centre (C.R.M., R.F., G.B.P., E.E.S.), Alberta Health Services, Calgary; Department of Psychology (E.L.M.), St. Francis Xavier University, Antigonish; and Division of Neurology and Department of Medicine (M.G., K.N., G.C.J., R.C.), Department of Biomedical Engineering (C.B.), and Neuroscience and Mental Health Institute (R.C.), University of Alberta, Edmonton, Canada.
Emily CoxFrom the Department of Clinical Neurosciences (A.E.B., C.R.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Hotchkiss Brain Institute (A.E.B., C.R.M., E.L.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Department of Radiology (C.R.M., E.L.M., R.F., G.B.P., E.E.S.), Department of Psychiatry (Z.I.), and Mathison Centre for Mental Health Research & Education (Z.I.), University of Calgary; Seaman Family MR Research Centre, Foothills Medical Centre (C.R.M., R.F., G.B.P., E.E.S.), Alberta Health Services, Calgary; Department of Psychology (E.L.M.), St. Francis Xavier University, Antigonish; and Division of Neurology and Department of Medicine (M.G., K.N., G.C.J., R.C.), Department of Biomedical Engineering (C.B.), and Neuroscience and Mental Health Institute (R.C.), University of Alberta, Edmonton, Canada.
Krista NellesFrom the Department of Clinical Neurosciences (A.E.B., C.R.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Hotchkiss Brain Institute (A.E.B., C.R.M., E.L.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Department of Radiology (C.R.M., E.L.M., R.F., G.B.P., E.E.S.), Department of Psychiatry (Z.I.), and Mathison Centre for Mental Health Research & Education (Z.I.), University of Calgary; Seaman Family MR Research Centre, Foothills Medical Centre (C.R.M., R.F., G.B.P., E.E.S.), Alberta Health Services, Calgary; Department of Psychology (E.L.M.), St. Francis Xavier University, Antigonish; and Division of Neurology and Department of Medicine (M.G., K.N., G.C.J., R.C.), Department of Biomedical Engineering (C.B.), and Neuroscience and Mental Health Institute (R.C.), University of Alberta, Edmonton, Canada.ORCID 0000-0003-4491-5758
Anna CharltonFrom the Department of Clinical Neurosciences (A.E.B., C.R.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Hotchkiss Brain Institute (A.E.B., C.R.M., E.L.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Department of Radiology (C.R.M., E.L.M., R.F., G.B.P., E.E.S.), Department of Psychiatry (Z.I.), and Mathison Centre for Mental Health Research & Education (Z.I.), University of Calgary; Seaman Family MR Research Centre, Foothills Medical Centre (C.R.M., R.F., G.B.P., E.E.S.), Alberta Health Services, Calgary; Department of Psychology (E.L.M.), St. Francis Xavier University, Antigonish; and Division of Neurology and Department of Medicine (M.G., K.N., G.C.J., R.C.), Department of Biomedical Engineering (C.B.), and Neuroscience and Mental Health Institute (R.C.), University of Alberta, Edmonton, Canada.ORCID 0000-0001-5588-5350
Richard FrayneFrom the Department of Clinical Neurosciences (A.E.B., C.R.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Hotchkiss Brain Institute (A.E.B., C.R.M., E.L.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Department of Radiology (C.R.M., E.L.M., R.F., G.B.P., E.E.S.), Department of Psychiatry (Z.I.), and Mathison Centre for Mental Health Research & Education (Z.I.), University of Calgary; Seaman Family MR Research Centre, Foothills Medical Centre (C.R.M., R.F., G.B.P., E.E.S.), Alberta Health Services, Calgary; Department of Psychology (E.L.M.), St. Francis Xavier University, Antigonish; and Division of Neurology and Department of Medicine (M.G., K.N., G.C.J., R.C.), Department of Biomedical Engineering (C.B.), and Neuroscience and Mental Health Institute (R.C.), University of Alberta, Edmonton, Canada.ORCID 0000-0003-0358-1210
Zahinoor IsmailFrom the Department of Clinical Neurosciences (A.E.B., C.R.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Hotchkiss Brain Institute (A.E.B., C.R.M., E.L.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Department of Radiology (C.R.M., E.L.M., R.F., G.B.P., E.E.S.), Department of Psychiatry (Z.I.), and Mathison Centre for Mental Health Research & Education (Z.I.), University of Calgary; Seaman Family MR Research Centre, Foothills Medical Centre (C.R.M., R.F., G.B.P., E.E.S.), Alberta Health Services, Calgary; Department of Psychology (E.L.M.), St. Francis Xavier University, Antigonish; and Division of Neurology and Department of Medicine (M.G., K.N., G.C.J., R.C.), Department of Biomedical Engineering (C.B.), and Neuroscience and Mental Health Institute (R.C.), University of Alberta, Edmonton, Canada.ORCID 0000-0002-5529-3731
Christian BeaulieuFrom the Department of Clinical Neurosciences (A.E.B., C.R.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Hotchkiss Brain Institute (A.E.B., C.R.M., E.L.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Department of Radiology (C.R.M., E.L.M., R.F., G.B.P., E.E.S.), Department of Psychiatry (Z.I.), and Mathison Centre for Mental Health Research & Education (Z.I.), University of Calgary; Seaman Family MR Research Centre, Foothills Medical Centre (C.R.M., R.F., G.B.P., E.E.S.), Alberta Health Services, Calgary; Department of Psychology (E.L.M.), St. Francis Xavier University, Antigonish; and Division of Neurology and Department of Medicine (M.G., K.N., G.C.J., R.C.), Department of Biomedical Engineering (C.B.), and Neuroscience and Mental Health Institute (R.C.), University of Alberta, Edmonton, Canada.
Glen C JicklingFrom the Department of Clinical Neurosciences (A.E.B., C.R.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Hotchkiss Brain Institute (A.E.B., C.R.M., E.L.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Department of Radiology (C.R.M., E.L.M., R.F., G.B.P., E.E.S.), Department of Psychiatry (Z.I.), and Mathison Centre for Mental Health Research & Education (Z.I.), University of Calgary; Seaman Family MR Research Centre, Foothills Medical Centre (C.R.M., R.F., G.B.P., E.E.S.), Alberta Health Services, Calgary; Department of Psychology (E.L.M.), St. Francis Xavier University, Antigonish; and Division of Neurology and Department of Medicine (M.G., K.N., G.C.J., R.C.), Department of Biomedical Engineering (C.B.), and Neuroscience and Mental Health Institute (R.C.), University of Alberta, Edmonton, Canada.
Richard M CamicioliFrom the Department of Clinical Neurosciences (A.E.B., C.R.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Hotchkiss Brain Institute (A.E.B., C.R.M., E.L.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Department of Radiology (C.R.M., E.L.M., R.F., G.B.P., E.E.S.), Department of Psychiatry (Z.I.), and Mathison Centre for Mental Health Research & Education (Z.I.), University of Calgary; Seaman Family MR Research Centre, Foothills Medical Centre (C.R.M., R.F., G.B.P., E.E.S.), Alberta Health Services, Calgary; Department of Psychology (E.L.M.), St. Francis Xavier University, Antigonish; and Division of Neurology and Department of Medicine (M.G., K.N., G.C.J., R.C.), Department of Biomedical Engineering (C.B.), and Neuroscience and Mental Health Institute (R.C.), University of Alberta, Edmonton, Canada.
G Bruce PikeFrom the Department of Clinical Neurosciences (A.E.B., C.R.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Hotchkiss Brain Institute (A.E.B., C.R.M., E.L.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Department of Radiology (C.R.M., E.L.M., R.F., G.B.P., E.E.S.), Department of Psychiatry (Z.I.), and Mathison Centre for Mental Health Research & Education (Z.I.), University of Calgary; Seaman Family MR Research Centre, Foothills Medical Centre (C.R.M., R.F., G.B.P., E.E.S.), Alberta Health Services, Calgary; Department of Psychology (E.L.M.), St. Francis Xavier University, Antigonish; and Division of Neurology and Department of Medicine (M.G., K.N., G.C.J., R.C.), Department of Biomedical Engineering (C.B.), and Neuroscience and Mental Health Institute (R.C.), University of Alberta, Edmonton, Canada.ORCID 0000-0001-8924-683X
Eric E SmithFrom the Department of Clinical Neurosciences (A.E.B., C.R.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Hotchkiss Brain Institute (A.E.B., C.R.M., E.L.M., B.S., A.S., A.M.Z., E.C., A.C., R.F., Z.I., G.B.P., E.E.S.), Department of Radiology (C.R.M., E.L.M., R.F., G.B.P., E.E.S.), Department of Psychiatry (Z.I.), and Mathison Centre for Mental Health Research & Education (Z.I.), University of Calgary; Seaman Family MR Research Centre, Foothills Medical Centre (C.R.M., R.F., G.B.P., E.E.S.), Alberta Health Services, Calgary; Department of Psychology (E.L.M.), St. Francis Xavier University, Antigonish; and Division of Neurology and Department of Medicine (M.G., K.N., G.C.J., R.C.), Department of Biomedical Engineering (C.B.), and Neuroscience and Mental Health Institute (R.C.), University of Alberta, Edmonton, Canada.ORCID 0000-0003-3956-1668

Funding

CIHR FDN-143290CIHR FDN-154317CIHR MOP-142175
6 · The paper itself

Abstract

BACKGROUND AND

objectivesReduced cerebrovascular reactivity is proposed to be a feature of cerebral amyloid angiopathy (CAA) but has not been measured directly. Employing a global vasodilatory stimulus (hypercapnia), this study assessed the relationships between cerebrovascular reactivity and MRI markers of CAA and cognitive function.

methodsIn a cross-sectional study, individuals with probable CAA, mild cognitive impairment, or dementia due to Alzheimer disease and healthy controls underwent neuropsychological testing and an MRI that included a 5% carbon dioxide challenge. Cerebrovascular reactivity was compared across groups controlling for age, sex, and the presence of hypertension, and its associations with MRI markers of CAA in participants with CAA and with cognition across all participants were determined using multivariable linear regression adjusting for group, age, sex, education, and the presence of hypertension.

resultsCerebrovascular reactivity data (mean ± SD) were available for 26 participants with CAA (9 female; 74.4 ± 7.7 years), 19 participants with mild cognitive impairment (5 female; 72.1 ± 8.5 years), 12 participants with dementia due to Alzheimer disease (4 female; 69.4 ± 6.6 years), and 39 healthy controls (30 female; 68.8 ± 5.4 years). Gray and whiter matter reactivity averaged across the entire brain was lower in participants with CAA and Alzheimer disease dementia compared to healthy controls, with a predominantly posterior distribution of lower reactivity in both groups. Higher white matter hyperintensity volume was associated with lower white matter reactivity (standardized coefficient [β], 95% CI -0.48, -0.90 to -0.01). Higher gray matter reactivity was associated with better global cognitive function (β 0.19, 0.03-0.36), memory (β 0.21, 0.07-0.36), executive function (β 0.20, 0.02-0.39), and processing speed (β 0.27, 0.10-0.45) and higher white matter reactivity was associated with higher memory (β 0.22, 0.08-0.36) and processing speed (β 0.23, 0.06-0.40).

conclusionsReduced cerebrovascular reactivity is a core feature of CAA and its assessment may provide an additional biomarker for disease severity and cognitive impairment.

Indexed as

Alzheimer DiseaseCerebral Amyloid AngiopathyHypertensionBrainCross-Sectional StudiesFemaleHumansMale

Identifiers

PMID35210294
PMCPMC9071369

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.