Evidence map›Paper›PMID 35209961›Full record

ArticlePsychological medicine2023

Altered prefrontal activation during the inhibition of eating responses in women with bulimia nervosa.

Laura A Berner, Samantha R Winter, Hasan Ayaz, Patricia A Shewokis, Meltem Izzetoglu, Rachel Marsh, Jennifer A Nasser, Alyssa J Matteucci, Michael R Lowe

Open access · greenAbstract read
In one paragraph

Article in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Bulimia nervosa.Nature reviews. Disease primers · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Prefrontal Cortex Recruitment to Food Stimuli Differs in Overweight/Obesity and Binge Eating Disorder.European eating disorders review : the journal of the Eating Disorders Association · 2026
    Article
  8. Review
  9. Review
  10. Glial cells in anorexia.Frontiers in cellular neuroscience · 2022
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Laura A BernerIcahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID https://orcid.org/0000-0002-1430-8028
Samantha R WinterGoogle Health, Google LLC, Mountain View, CA, USA.
Hasan AyazDrexel University, Philadelphia, PA, USA.
Patricia A ShewokisDrexel University, Philadelphia, PA, USA.
Meltem IzzetogluVillanova University, Villanova, PA, USA.
Rachel MarshColumbia University Irving Medical Center and the New York State Psychiatric Institute, New York, NY, USA.
Jennifer A NasserDrexel University, Philadelphia, PA, USA.
Alyssa J MatteucciThe Wharton School, University of Pennsylvania, Philadelphia, PA, USA.
Michael R LoweDrexel University, Philadelphia, PA, USA.
Drexel University · USChildren's Hospital of Philadelphia · USColumbia University Irving Medical Center · USGoogle (United States) · USIcahn School of Medicine at Mount Sinai · USUniversity of Pennsylvania · USVillanova University · US

Funding

Self-regulatory Control and Eating: A Neuroimaging Study of Bulimia NervosaF31MH097406 · NIMH · DREXEL UNIVERSITY · PI BERNER, LAURA A. · 2012 to 2013
$65k
NIMH NIH HHS F31 MH097406
6 · The paper itself

Abstract

backgroundThe sense of 'loss of control' (LOC), or a feeling of being unable to stop eating or control what or how much one is eating, is the most salient aspect of binge eating. However, the neural alterations that may contribute to this experience and eating behavior remain poorly understood.

methodsWe used functional near-infrared spectroscopy (fNIRS) to measure activation in the prefrontal cortices of 23 women with bulimia nervosa (BN) and 23 healthy controls (HC) during two tasks: a novel go/no-go task requiring inhibition of eating responses, and a standard go/no-go task requiring inhibition of button-pressing responses.

resultsWomen with BN made more commission errors on both tasks. BN subgroups with the most severe LOC eating (

conclusionsResults provide initial evidence that diminished PFC activation may directly contribute to more severe eating-specific control deficits in BN. Our findings support vmPFC and vlPFC dysfunction as promising treatment targets, and indicate that eating-specific tasks and fNIRS may be useful tools for identifying neural mechanisms underlying dysregulated eating.

Indexed as

Binge-Eating DisorderBulimiaBulimia NervosaFemaleHumansMagnetic Resonance ImagingPrefrontal CortexBulimia nervosafNIRSinhibitory controlloss-of-control eatingprefrontal cortex

Identifiers

PMID35209961
PMCPMC9476324
OpenAlexW4214513324

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.