Evidence map›Paper›PMID 35209914›Full record

ReviewWorld journal of surgical oncology2022

Long-term survival outcomes of esophageal cancer after minimally invasive Ivor Lewis esophagectomy.

Keouna Pather, Erin M Mobley, Christina Guerrier, Rhemar Esma, Heather Kendall, Ziad T Awad

Open access · goldAbstract readReview
In one paragraph

Review in World journal of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Keouna PatherDepartment of Surgery, University of Florida College of Medicine - Jacksonville, Jacksonville, Florida, USA. keounapather@gmail.com.ORCID http://orcid.org/0000-0002-0884-6612
Erin M MobleyDepartment of Surgery, University of Florida College of Medicine - Jacksonville, Jacksonville, Florida, USA.
Christina GuerrierDepartment of Surgery, University of Florida College of Medicine - Jacksonville, Jacksonville, Florida, USA.
Rhemar EsmaUF Health Jacksonville, Jacksonville, Florida, USA.
Heather KendallUF Health Jacksonville, Jacksonville, Florida, USA.
Ziad T AwadDepartment of Surgery, University of Florida College of Medicine - Jacksonville, Jacksonville, Florida, USA.
University of Florida · USUniversity of Florida Health · USUniversity of North Florida · US

Funding

The University of Florida Jacksonville Aging Studies Center (JAX-ASCENT)R33AG056540 · NIA · UNIVERSITY OF FLORIDA · PI ANTON, STEPHEN D · 2017 to 2021
$3.8M
institute on aging, college of medicine, university of florida 5R33AG056540NIA NIH HHS R33 AG056540
6 · The paper itself

Abstract

objectivesThe aim of this study was to determine the long-term overall and disease-free survival and factors associated with overall survival in patients with esophageal cancer undergoing a totally minimally invasive Ivor Lewis esophagectomy (MILE) at a safety-net hospital.

methodsThis was a single-center retrospective review of consecutive patients who underwent MILE from September 2013 to November 2017. Overall and disease-free survival were analyzed by Kaplan-Meier estimates, and hazard ratios (HR) were derived from multivariable Cox regression models.

resultsNinety-six patients underwent MILE during the study period. Overall survival at 1, 3, and 5 years was 83.2%, 61.9%, and 55.9%, respectively. Disease-free survival at 1, 3, and 5 years was 83.2%, 60.6%, and 47.5%, respectively. Overall survival (p < 0.001) and disease-free survival (p < 0.001) differed across pathological stages. By multivariable analysis, increasing age (HR, 1.06; p = 0.02), decreasing Karnofsky performance status score (HR, 0.94; p = 0.002), presence of stage IV disease (HR, 5.62; p = 0.002), locoregional recurrence (HR, 2.94; p = 0.03), and distant recurrence (HR, 4.78; p < 0.001) were negatively associated with overall survival. Overall survival significantly declined within 2 years and was independently associated with stage IV disease (HR, 3.29; p = 0.04) and distant recurrence (HR, 5.78; p < 0.001).

conclusionMILE offers favorable long-term overall and disease-free survival outcomes. Age, Karnofsky performance status score, stage IV, and disease recurrence are shown to be prognostic factors of overall survival. Prospective studies comparing long-term outcomes after different MIE approaches are warranted to validate survival outcomes after MILE.

Indexed as

Esophageal NeoplasmsEsophagectomyHumansMinimally Invasive Surgical ProceduresNeoplasm Recurrence, LocalPostoperative ComplicationsProspective StudiesRetrospective StudiesTreatment OutcomeCancer survivalEsophageal malignancyIvor Lewis esophagectomyThoracic surgeryThoracolaparoscopic esophagectomy

Identifiers

PMID35209914
PMCPMC8876443
OpenAlexW4214537886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.