ArticleBMC gastroenterology2022
Helicobacter pylori infection is not an independent risk factor of non-alcoholic fatty liver disease in China.
Article in BMC gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Bidirectional relationship betweenFrontiers in nutrition · 2024Pooled it
- Relationship ofCanadian journal of gastroenterology & hepatology · 2023Pooled it
- Associations ofTherapeutic advances in gastroenterology · 2026Article
- Association ofJGH open : an open access journal of gastroenterology and hepatology · 2025Review
- Association betweenWorld journal of hepatology · 2025Article
- Article
- Overweight andFrontiers in cellular and infection microbiology · 2025Article
- Prevalence and risk factors associated with metabolic dysfunction-associated steatohepatitis in patients withWorld journal of hepatology · 2024Article
- The interplay between Helicobacter pylori infection and rs738409 PNPLA3 in metabolic dysfunction-associated steatotic liver disease.PloS one · 2024Article
- Alcoholic liver disease in relation to cancer incidence and mortality: Findings from a large, matched cohort study in South Korea.Cancer medicine · 2023Article
- Article
- The Prevalence of Liver Cytolysis in Children withChildren (Basel, Switzerland) · 2022Article
- No evidence for a causal link betweenFrontiers in microbiology · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundThe role of Helicobacter pylori (H. pylori) infection in the development of non-alcoholic fatty liver disease (NAFLD) remains controversial. The exact relationship requires further investigation. This study aimed to determine the association between them in China.
methodsA retrospective study was conducted on 71,633 participants who underwent physical examinations.
resultsBody mass index (BMI), blood pressure (BP), and triglyceride (TG) levels were higher in participants with H. pylori infection than in those without H. pylori infection. While the levels of high-density lipoprotein cholesterol (HDL-C) for participants with H. pylori infection was lower than without H. pylori infection (P < 0.001). After adjusting for confounding factors (age, sex, BMI, BP, Scr, BUN, LDL-C, HDL-C, triglycerides, FBG and HbA1c), multivariate logistic regression analysis indicated that there was no independent relationship between them (P = 0.574). Subgroup analysis (stratified by sex, age, BMI, hypertension, diabetes and dyslipidemia) showed that H. pylori infection was not included as an independent risk factor for NAFLD. Moreover, the different grades of NAFLD were not related to H. pylori infection.
conclusionsThese results indicate that H. pylori infection is not an independent risk factor for NAFLD in China.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.