Evidence map›Paper›PMID 35209862›Full record

ArticleBMC infectious diseases2022

Respiratory failure as the prominent manifestation of entecavir-associated mitochondrial myopathy: a case report.

Xiao Lin, Aixin Song, Sujun Zheng, Xinyue Chen

Open access · goldAbstract readCase Reports
In one paragraph

Article in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. A Rare Case of Myopathy Associated with Entecavir Initiation.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Xiao LinFirst Department of Liver Disease Center, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Aixin SongFirst Department of Liver Disease Center, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Sujun ZhengFirst Department of Liver Disease Center, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Xinyue ChenFirst Department of Liver Disease Center, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China. chenxydoc@ccmu.edu.cn.ORCID http://orcid.org/0000-0001-9569-4540
Capital Medical University · CN

Funding

This study was supported by Capital Health Research and Development Projects 2020-1-2181
6 · The paper itself

Abstract

backgroundMitochondrial myopathy caused by the long-term use of nucleos(t)ide analogue in patients with chronic hepatitis B (CHB) is mostly characterized by myasthenia and myalgia. Cases with respiratory failure as the prominent manifestation and multisystem symptoms have not been reported. CASE REPORT: We report a case of mitochondrial myopathy associated with the long-term use of entecavir for CHB. The patient was a 54-year-old male who was treated with entecavir for 9 years. During the treatment, hepatitis B virus (HBV) DNA was negative and liver function was normal. However, generalized fatigue, poor appetite, dysosmia and other discomforts gradually presented starting at the 5 DISCUSSION: Mitochondrial myopathy is a rare side effect of entecavir and can be diagnosed by muscle biopsy. Although the incidence is extremely low, but the severe cases can lead to respiratory failure. We should receive adequate attention in clinical practice.

Indexed as

Hepatitis B, ChronicMitochondrial MyopathiesRespiratory InsufficiencyAntiviral AgentsGuanineHepatitis B virusHumansMaleMiddle AgedTreatment OutcomeAntiviral AgentsentecavirGuanineDysosmiaEntecavirMitochondrial myopathyMyastheniaRespiratory failure

Identifiers

PMID35209862
PMCPMC8867453
OpenAlexW4213432670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.