Evidence map›Paper›PMID 35209743›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2022

Comparison of three novel radiotracers for GluN2B-containing NMDA receptors in non-human primates:

Kelly Smart, Ming-Qiang Zheng, Hazem Ahmed, Hanyi Fang, Yuping Xu, Lisheng Cai, Daniel Holden, Michael Kapinos, Achi Haider, Zachary Felchner and 7 more

Open access · greenAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. A Study of 3-Substituted 7-Methoxy-2,3,4,5-tetrahydro-1Molecules (Basel, Switzerland) · 2026
    Article
  2. Toward Imaging of the GABA Transporter Type 1 In Vivo: Quantitative Evaluation of 4 Novel PET Radiotracers in Nonhuman Primates.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  3. Review
  4. Review
  5. Evaluation of (Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  6. Development and Validation of [Pharmaceuticals (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Kelly SmartYale School of Medicine, Yale PET Center, New Haven, Connecticut, USA.
Ming-Qiang ZhengYale School of Medicine, Yale PET Center, New Haven, Connecticut, USA.
Hazem AhmedYale School of Medicine, Yale PET Center, New Haven, Connecticut, USA.
Hanyi FangYale School of Medicine, Yale PET Center, New Haven, Connecticut, USA.
Yuping XuYale School of Medicine, Yale PET Center, New Haven, Connecticut, USA.
Lisheng CaiMolecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland, USA.
Daniel HoldenYale School of Medicine, Yale PET Center, New Haven, Connecticut, USA.
Michael KapinosYale School of Medicine, Yale PET Center, New Haven, Connecticut, USA.
Achi HaiderInstitute of Pharmaceutical Sciences, Zurich, Switzerland.
Zachary FelchnerYale School of Medicine, Yale PET Center, New Haven, Connecticut, USA.
Jim R RopchanYale School of Medicine, Yale PET Center, New Haven, Connecticut, USA.
Gilles TamagnanYale School of Medicine, Yale PET Center, New Haven, Connecticut, USA.
Robert B InnisMolecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland, USA.
Victor W PikeMolecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland, USA.
Simon M AmetameyDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, USA.
Yiyun HuangYale School of Medicine, Yale PET Center, New Haven, Connecticut, USA.
Richard E CarsonYale School of Medicine, Yale PET Center, New Haven, Connecticut, USA.
Yale Cancer Center · USYale University · USNational Institute of Mental Health · USWuhan Union Hospital · CN

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
PET Radiopharmaceutical SciencesZIAMH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2009 to 2025
$69.8M
Translational Evaluation Of PET RadiotracersZIAMH002795 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2009 to 2025
$32.0M
A Program for Innovative PET Radioligand Development and Application - A Translational Toolbox for Treatments for Mental HealthU01MH107803 · NIMH · YALE UNIVERSITY · PI Richard E. Carson, YIYUN HENRY HUANG · 2015 to 2026
$13.7M
PET Radiopharmaceutical SciencesZ01MH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2002 to 2008
$7.4M
Preclinical Evaluation Of PET RadiotracersZ01MH002795 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2002 to 2008
$3.2M
High Resolution Tandem Mass Spectrometer to Meet Growing Demand for Proteomics at YaleS10OD023651 · OD · YALE UNIVERSITY · PI LAM, TUKIET T · 2018 to 2018
$572k
6500 QTrap Mass Spectrometer for Yale UniversityS10OD018034 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2014 to 2014
$514k
An Ultra-Performance Liquid Chromatography System to Support Metabolomics at Yale UniversityS10OD019967 · OD · YALE UNIVERSITY · PI LAM, TUKIET T · 2015 to 2015
$135k
Intramural NIH HHS Z01 MH002793Intramural NIH HHS Z01 MH002795Intramural NIH HHS ZIA MH002793Intramural NIH HHS ZIA MH002795NCATS NIH HHS UL1 TR001863NIH HHS S10 OD018034NIH HHS S10 OD019967NIH HHS S10 OD023651NIMH NIH HHS U01 MH107803
6 · The paper itself

Abstract

The NMDA receptor GluN2B subunit is a target of interest in neuropsychiatric disorders but to date there is no selective radiotracer available to quantify its availability

Indexed as

RadiopharmaceuticalsReceptors, N-Methyl-D-AspartateAnimalsBrainMacaca mulattaPositron-Emission TomographyRadiopharmaceuticalsReceptors, N-Methyl-D-AspartateGluN2B subunitglutamateNMDA receptorPositron emission tomography(R)-[11C]NR2B-Me(R)-[18F]OF-Me-NB1(S)-[18F]OF-NB1

Identifiers

PMID35209743
PMCPMC9274863
OpenAlexW4214617584

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.