Evidence map›Paper›PMID 35209727›Full record

ArticleHypertension (Dallas, Tex. : 1979)2022

Hypertensive Disorders of Pregnancy With and Without Prepregnancy Hypertension Are Associated With Incident Maternal Kidney Disease Subsequent to Delivery.

Angela M Malek, Kelly J Hunt, Tanya N Turan, Julio Mateus, Daniel T Lackland, Anika Lucas, Dulaney A Wilson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Angela M MalekDepartment of Public Health Sciences (A.M.M., K.J.H., D.A.W.), Medical University of South Carolina, Charleston.ORCID 0000-0001-5691-5347
Kelly J HuntDepartment of Public Health Sciences (A.M.M., K.J.H., D.A.W.), Medical University of South Carolina, Charleston.
Tanya N TuranDepartment of Neurology (T.N.T., D.T.L.), Medical University of South Carolina, Charleston.ORCID 0000-0001-5399-8845
Julio MateusDepartment of Obstetrics & Gynecology, Maternal-Fetal Medicine Division, Atrium Health, Charlotte, NC (J.M.).
Daniel T LacklandDepartment of Neurology (T.N.T., D.T.L.), Medical University of South Carolina, Charleston.ORCID 0000-0001-5733-6283
Anika LucasDepartment of Medicine, Division of Nephrology, Duke University, Durham, NC (A.L.).
Dulaney A WilsonDepartment of Public Health Sciences (A.M.M., K.J.H., D.A.W.), Medical University of South Carolina, Charleston.ORCID 0000-0003-4726-7848
Medical University of South Carolina · USCarolinas Medical Center · USDuke University · US

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
Long term maternal and infant complications of pre-eclampsiaK01HL138273 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MALEK, ANGELA M · 2018 to 2022
$714k
NCATS NIH HHS UL1 TR001450NHLBI NIH HHS K01 HL138273NHLBI NIH HHS L30 HL149032
6 · The paper itself

Abstract

backgroundMaternal morbidity and mortality are related to prepregnancy hypertensive disease and hypertensive disorders of pregnancy (HDP) including preeclampsia (41.1% of HDP), eclampsia (1.3% of HDP), and gestational hypertension (39.9% of HDP). Less information is available on the risk of maternal kidney disease and potential racial/ethnic differences following a hypertensive condition during pregnancy. Our objective was to examine the relationships between HDP and prepregnancy hypertension with maternal incident kidney disease subsequent to delivery (up to 3, 5, and 14 years) with consideration of racial/ethnic differences.

methodsIn a retrospective cohort study, 391 838 women 12 to 49 years of age had a live birth in South Carolina between 2004 and 2016; 35.1% non-Hispanic Black (NHB) and 64.9% non-Hispanic White (NHW). Hospitalization, emergency department, and birth certificate data defined prepregnancy hypertension and HDP. Hospitalization and death certificate data identified incident kidney disease.

results317 006 (80.8%) women experienced neither condition, 1473 (0.4%) had prepregnancy hypertension, 64 050 (16.3%) had HDP, and 9662 (2.5%) had both conditions (prepregnancy hypertension with superimposed HDP, ie, preeclampsia). Five years after delivery, incident kidney disease risk was increased for NHB and NHW women with HDP (NHB: hazard ratio, 2.30 [95% CI, 1.94-2.73]; NHW: hazard ratio, 1.97 [95% CI, 1.64-2.37]) and with both conditions (NHB: hazard ratio, 3.88 [95% CI, 3.05-4.93]; NHW: hazard ratio, 1.86 [95% CI, 1.20-2.87]) compared with counterparts with neither condition after adjustment (

conclusionsIncreased kidney disease risk 5 years after delivery was observed for women with HDP and with both compared with neither condition, with associated risk higher in NHB than NHW women.

Indexed as

Hypertension, Pregnancy-InducedKidney DiseasesPre-EclampsiaEthnicityFemaleHumansMalePregnancyRetrospective Studieseclampsiahospitalizationlive birthmaternal mortalityrenal diseasestillbirth

Identifiers

PMID35209727
PMCPMC8917087
OpenAlexW4214609079

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.