Evidence map›Paper›PMID 35209718›Full record

ArticleCirculation research2022

B-1b Cells Possess Unique bHLH-Driven P62-Dependent Self-Renewal and Atheroprotection.

Tanyaporn Pattarabanjird, Melissa Marshall, Aditi Upadhye, Prasad Srikakulapu, James C Garmey, Antony Haider, Angela M Taylor, Esther Lutgens, Coleen A McNamara

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 38 citations in OpenAlex.

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  9. Tipping the Scale: Atheroprotective IgM-Producing B Cells in Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Tanyaporn PattarabanjirdCarter Immunology Center (T.P., M.M., P.S., J.C.G., A.H., C.A.M.), University of Virginia, Charlottesville. Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität, Munich, Germany.ORCID 0000-0003-0994-1491
Melissa MarshallCarter Immunology Center (T.P., M.M., P.S., J.C.G., A.H., C.A.M.), University of Virginia, Charlottesville. Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität, Munich, Germany.ORCID 0000-0001-6402-5942
Aditi UpadhyeCardiovascular Research Center (T.P., M.M., A.U., P.S., J.C.G., A.H., C.A.M.), University of Virginia, Charlottesville. Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität, Munich, Germany.
Prasad SrikakulapuCarter Immunology Center (T.P., M.M., P.S., J.C.G., A.H., C.A.M.), University of Virginia, Charlottesville. Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität, Munich, Germany.
James C GarmeyCarter Immunology Center (T.P., M.M., P.S., J.C.G., A.H., C.A.M.), University of Virginia, Charlottesville. Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität, Munich, Germany.ORCID 0000-0001-7456-8617
Antony HaiderCarter Immunology Center (T.P., M.M., P.S., J.C.G., A.H., C.A.M.), University of Virginia, Charlottesville. Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität, Munich, Germany.
Angela M TaylorDivision of Cardiovascular Medicine, Department of Medicine (A.M.T., C.A.M.), University of Virginia, Charlottesville. Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität, Munich, Germany.
Esther LutgensGerman Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Germany (E.L.).
Coleen A McNamaraCarter Immunology Center (T.P., M.M., P.S., J.C.G., A.H., C.A.M.), University of Virginia, Charlottesville. Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität, Munich, Germany.ORCID 0000-0002-0049-9986
Ludwig-Maximilians-Universität München · DEGerman Centre for Cardiovascular Research · DE

Funding

Local B-1 Regulation of AtherosclerosisR01HL136098 · NHLBI · UNIVERSITY OF VIRGINIA · PI MCNAMARA, COLEEN A · 2017 to 2020
$3.1M
Id3 and VSMC in Murine and Human AtherosclerosisR01HL148109 · NHLBI · UNIVERSITY OF VIRGINIA · PI MCNAMARA, COLEEN A · 2019 to 2022
$2.7M
NHLBI NIH HHS R01 HL136098NHLBI NIH HHS R01 HL148109
6 · The paper itself

Abstract

backgroundB1a and B1b lymphocytes produce IgM that inactivates oxidation-specific epitopes (IgM

methodsBulk RNA sequencing was utilized to identify differentially expressed genes in B1a and B1b cells from

resultsThrough RNA sequencing, P62 was found to be enriched in

conclusionsThis study unveils a novel role for P62 in driving BAFF-induced B1b cell proliferation and IgM

Indexed as

AtherosclerosisB-Lymphocyte SubsetsAnimalsB-LymphocytesHumansImmunoglobulin MMiceMice, KnockoutImmunoglobulin Matherosclerosiscardiovascular diseasesimmunoglobulin Minflammationproliferation

Identifiers

PMID35209718
PMCPMC9075598
OpenAlexW4214518129

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.