Evidence map›Paper›PMID 35209214›Full record

ArticleMolecules (Basel, Switzerland)2022

Tocopheryl Phosphate Inhibits Rheumatoid Arthritis-Related Gene Expression In Vitro and Ameliorates Arthritic Symptoms in Mice.

Susumu Hama, Naoko Kirimura, Aki Obara, Hirokatsu Takatsu, Kentaro Kogure

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06915701 ("Evaluation of the Effect of Vitamin E), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06915701 phase2 / phase3recruitingnot on this mapstarted 2026, after this paper: background citation

"Evaluation of the Effect of Vitamin E (α-tocopherol) Supplementation on Clinical Activity and Inflammation in Patients With Rheumatoid Arthritis"

TypeinterventionalSponsorUniversity of GuadalajaraRan2026 to 2027Enrolled46ConditionsRheumatoid ArthritisArmsWill take vitamin E 800mg/day, Will take 200mg/day magnesium oxide placebo.
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Susumu HamaFaculty of Pharmacy, Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo 202-8585, Japan.
Naoko KirimuraDepartment of Biophysical Chemistry, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan.
Aki ObaraDepartment of Analytical Chemistry, Kyorin University, Tokyo 181-8612, Japan.
Hirokatsu TakatsuDepartment of Analytical Chemistry, Kyorin University, Tokyo 181-8612, Japan.
Kentaro KogureGraduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8505, Japan.
Kyorin University · JPKyoto Pharmaceutical University · JPMusashino University · JPTokushima University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-rheumatoid arthritis (RA) effects of α-tocopherol (α-T) have been shown in human patients in a double-blind trial. However, the effects of α-T and its derivatives on fibroblast-like synoviocytes (FLS) during the pathogenesis of RA remain unclear. In the present study, we compared the expression levels of genes related to RA progression in FLS treated with α-T, succinic ester of α-T (TS), and phosphate ester of α-T (TP), as determined via RT-PCR. The mRNA levels of interleukin (IL)-6, tumor necrosis factor-α (TNF-α), matrix metalloproteinase (MMP)-3, and MMP-13 were reduced by treatment with TP without cytotoxicity, while α-T and TS did not show such effects. Furthermore, intraperitoneal injection of TP ameliorated the edema of the foot and joint and improved the arthritis score in laminarin-induced RA model mice. Therefore, TP exerted anti-RA effects through by inhibiting RA-related gene expression.

Indexed as

alpha-TocopherolAnimalsAntirheumatic AgentsArthritis, RheumatoidCytokinesGene Expression RegulationGlucansHumansMatrix Metalloproteinase 13Matrix Metalloproteinase 3Micealpha-Tocopherolalpha-tocopherol phosphateAntirheumatic AgentsCytokinesGlucanslaminaranMatrix Metalloproteinase 13Matrix Metalloproteinase 3Mmp13 protein, mouseMmp3 protein, mouserheumatoid arthritistocopheryl phosphatetocopheryl succinateα-tocopherol

Identifiers

PMID35209214
PMCPMC8880618
OpenAlexW4214480611

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.