Evidence map›Paper›PMID 35209191›Full record

ReviewMolecules (Basel, Switzerland)2022

BODIPY Conjugates as Functional Compounds for Medical Diagnostics and Treatment.

Elena Antina, Natalia Bumagina, Yuriy Marfin, Galina Guseva, Liliya Nikitina, Dmitry Sbytov, Felix Telegin

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 93 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Self-Assembled (Aza)BODIPY Dyes for Biomedical in Vivo Imaging.Angewandte Chemie (International ed. in English) · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. MultifunctionalRSC advances · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Elena AntinaG.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya St., 153045 Ivanovo, Russia.
Natalia BumaginaG.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya St., 153045 Ivanovo, Russia.
Yuriy MarfinInorganic Chemistry Department, Ivanovo State University of Chemistry and Technology, 7 Sheremetevskiy Ave., 153000 Ivanovo, Russia.
Galina GusevaG.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya St., 153045 Ivanovo, Russia.ORCID 0000-0002-5852-0661
Liliya NikitinaDepartment of General and Organic Chemistry, Kazan State Medical University, 49 Butlerova St., 420012 Kazan, Russia.ORCID 0000-0003-2113-5732
Dmitry SbytovInorganic Chemistry Department, Ivanovo State University of Chemistry and Technology, 7 Sheremetevskiy Ave., 153000 Ivanovo, Russia.
Felix TeleginInorganic Chemistry Department, Ivanovo State University of Chemistry and Technology, 7 Sheremetevskiy Ave., 153000 Ivanovo, Russia.ORCID 0000-0002-8626-2583
Institute of Solution Chemistry · RUIvanovo State University of Chemistry and Technology · RUKazan State Medical University · RU

Funding

Russian Science Foundation 19-73-10107Russian Science Foundation 20-63-47026
6 · The paper itself

Abstract

Fluorescent dyes absorbing and emitting in the visible and near-IR regions are promising for the development of fluorescent probes for labeling and bio-visualization of body cells. The ability to absorb and emit in the long-wavelength region increases the efficiency of recording the spectral signals of the probes due to the higher permeability of the skin layers. Compared to other fluorescent dyes, BODIPYs are attractive due to their excellent photophysical properties-narrow absorption and emission, intense fluorescence, simple signal modulation for the practical applications. As part of conjugates with biomolecules, BODIPY could act as a biomarker, but as therapeutic agent, which allows solving several problems at once-labeling or bioimaging and treatment based on the suppression of pathogenic microflora and cancer cells, which provides a huge potential for practical application of BODIPY conjugates in medicine. The review is devoted to the discussion of the recent, promising directions of BODIPY application in the field of conjugation with biomolecules. The first direction is associated with the development of BODIPY conjugates with drugs, including compounds of platinum, paclitaxel, chlorambucil, isoxazole, capsaicin, etc. The second direction is devoted to the labeling of vitamins, hormones, lipids, and other biomolecules to control the processes of their transport, localization in target cells, and metabolism. Within the framework of the third direction, the problem of obtaining functional optically active materials by conjugating BODIPY with other colored and fluorescent particles, in particular, phthalocyanines, is being solved.

Indexed as

Drug DevelopmentMolecular Diagnostic TechniquesBoron CompoundsChemical PhenomenaDrug Delivery SystemsFluorescent DyesHumansMolecular ImagingMolecular StructureSpectrum Analysis4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneBoron CompoundsFluorescent DyesbiomarkerBODIPYconjugatedrug deliveryfluorescent labelluminophore

Identifiers

PMID35209191
PMCPMC8877204
OpenAlexW4213369712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.