Evidence map›Paper›PMID 35209172›Full record

ArticleMolecules (Basel, Switzerland)2022

Vincamine Modulates the Effect of Pantoprazole in Renal Ischemia/Reperfusion Injury by Attenuating MAPK and Apoptosis Signaling Pathways.

Michael A Fawzy, Sherif A Maher, Mahmoud A El-Rehany, Nermeen N Welson, Nisreen K A Albezrah, Gaber El-Saber Batiha, Moustafa Fathy

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  15. A New EGFR Inhibitor fromCurrent issues in molecular biology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michael A FawzyDepartment of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.ORCID 0000-0002-0456-9021
Sherif A MaherDepartment of Biochemistry, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt.
Mahmoud A El-RehanyDepartment of Biochemistry, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt.
Nermeen N WelsonDepartment of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Beni-Suef University, Beni-Suef 62511, Egypt.
Nisreen K A AlbezrahDepartment of Obstetrics and Gynecology, College of Medicine, Taif University, Taif 21944, Saudi Arabia.
Gaber El-Saber BatihaDepartment of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt.
Moustafa FathyDepartment of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.ORCID 0000-0002-0734-5007

Funding

Taif University Supporting Project number (TURSP-2020/235)
6 · The paper itself

Abstract

Pantoprazole has an antioxidant function against reactive oxygen species (ROS). Vincamine, a herbal candidate, is an indole alkaloid of clinical use against brain sclerosis. The aim of the present experiment is to evaluate, on a molecular level for the first time, the value of vincamine in addition to pantoprazole in treating experimentally induced renal ischemia/reperfusion injury (IRI). One-hundred-and-twenty-eight healthy male Wistar albino rats were included. Serum creatinine, blood urea nitrogen, and malondialdehyde levels were assessed. ELISA was used to estimate the pro-inflammatory cytokines. The expression of

Indexed as

AnimalsApoptosisBiomarkersBiopsyCytokinesDisease ManagementDisease Models, AnimalDisease SusceptibilityImmunohistochemistryInflammation MediatorsKidney DiseasesMaleMAP Kinase Signaling SystemPantoprazoleRatsReperfusion InjuryBiomarkersCytokinesInflammation MediatorsPantoprazoleVincamineapoptosisMAPKpantoprazolerenal ischemia/reperfusion injuryROSvincamine

Identifiers

PMID35209172
PMCPMC8879001

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.