Evidence map›Paper›PMID 35209152›Full record

ArticleMolecules (Basel, Switzerland)2022

Structure-Activity Relationship of the Thiacalix[4]arenes Family with Sulfobetaine Fragments: Self-Assembly and Cytotoxic Effect against Cancer Cell Lines.

Luidmila Yakimova, Aisylu Kunafina, Aigul Nugmanova, Pavel Padnya, Alexandra Voloshina, Konstantin Petrov, Ivan Stoikov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luidmila YakimovaA.M. Butlerov' Chemistry Institute, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.ORCID 0000-0003-3956-6637
Aisylu KunafinaA.M. Butlerov' Chemistry Institute, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.
Aigul NugmanovaA.M. Butlerov' Chemistry Institute, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.
Pavel PadnyaA.M. Butlerov' Chemistry Institute, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.ORCID 0000-0002-1924-8028
Alexandra VoloshinaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov Street, 420088 Kazan, Russia.
Konstantin PetrovArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov Street, 420088 Kazan, Russia.
Ivan StoikovA.M. Butlerov' Chemistry Institute, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.ORCID 0000-0002-3019-7866

Funding

Russian Science Foundation 18-73-10094
6 · The paper itself

Abstract

Regulating the structure of macrocyclic host molecules and supramolecular assemblies is crucial because the structure-activity relationship often plays a role in governing the properties of these systems. Herein, we propose and develop an approach to the synthesis of the family of sulfobetaine functionalized thiacalix[4]arenes with regulation of the self-assembly and cytotoxic effect against cancer cell lines. The dynamic light scattering method showed that the synthesized macrocycles in

Indexed as

Antineoplastic AgentsBetaineCell LineCell SurvivalChemistry Techniques, SyntheticHumansMagnetic Resonance SpectroscopyMetalsMolecular StructurePhenolsSolubilityStructure-Activity RelationshipSulfidesAntineoplastic AgentsBetaineMetalsPhenolsSulfidessulfobetainethiacalix(4)arenecancer cell linescytotoxicityself-assemblysilver ionssulfobetainesthiacalixarene

Identifiers

PMID35209152
PMCPMC8879733

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.