The Hydrophobicity and Antifungal Potentiation of Burkholdine Analogues.

Hiroyuki Konno, Mio Sasaki, Hinata Sano, Keima Osawa, Kazuto Nosaka, Shigekazu Yano

Open access · goldAbstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

1.2field-weighted citation impact, top 23% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

Ecological Diversity, Metabolic Versatility, and Biotechnological Applications ofAntibiotics (Basel, Switzerland) · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hiroyuki KonnoDepartment of Biological Engineering, Graduate School of Science and Engineering, Yamagata University, Yonezawa 992-8510, Japan.ORCID 0000-0002-6629-6102

Mio SasakiDepartment of Biological Engineering, Graduate School of Science and Engineering, Yamagata University, Yonezawa 992-8510, Japan.

Hinata SanoDepartment of Biological Engineering, Graduate School of Science and Engineering, Yamagata University, Yonezawa 992-8510, Japan.

Keima OsawaDepartment of Biological Engineering, Graduate School of Science and Engineering, Yamagata University, Yonezawa 992-8510, Japan.

Kazuto NosakaFaculty of Pharmaceutical Science, Mukogawa Women's University, Nishinomiya 663-8179, Japan.

Shigekazu YanoDepartment of Biological Engineering, Graduate School of Science and Engineering, Yamagata University, Yonezawa 992-8510, Japan.

Yamagata University · JPMukogawa Women's University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The burkholdines are a family of cyclic lipopeptides reported to exhibit antifungal activity. We synthesized a series of 18 burkholdine analogues in good yield by conventional Fmoc-SPPS followed by cyclization with DIPCI/HOBt in the solution phase. Although none of the synthesized peptides exhibited antifungal activity, several did potentiate the antibiotic effect of the antibiotic G418, including the Thr-bearing Bk analogue (

Indexed as

Antifungal AgentsHydrophobic and Hydrophilic InteractionsLipopeptidesAntifungal AgentsburkholdineLipopeptidesantifungal activityburkholdinecyclic octalipopeptidepotentiation effect

Identifiers

PMID35208979

DOI10.3390/molecules27041191

PMCPMC8877233

OpenAlexW4211262168

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.