Evidence map›Paper›PMID 35208960›Full record

ArticleMolecules (Basel, Switzerland)2022

3, 3'- (3, 5-DCPBC) Down-Regulates Multiple Phosphokinase Dependent Signal Transduction Pathways in Malignant Melanoma Cells through Specific Diminution of EGFR

Qurat-Ul-Ain, Abhijit Basu, M Iqbal Choudhary, Karin Scharffetter-Kochanek

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Qurat-Ul-AinDepartment of Dermatology and Allergic Diseases, Ulm University, 89081 Ulm, Germany.ORCID 0000-0003-4092-6900
Abhijit BasuDepartment of Dermatology and Allergic Diseases, Ulm University, 89081 Ulm, Germany.
M Iqbal ChoudharyDr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Karin Scharffetter-KochanekDepartment of Dermatology and Allergic Diseases, Ulm University, 89081 Ulm, Germany.
Universität Ulm · DEUniversity of California, San Francisco · USUniversity of Karachi · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melanoma is the most dangerous skin malignancy due to its strong metastatic potential with high mortality. Activation of crucial signaling pathways enforcing melanoma progression depends on phosphorylation of distinct tyrosine kinases and oxidative stress. We here investigated the effect of a

Indexed as

CoumarinsMelanomaCell Line, TumorDown-RegulationErbB ReceptorsGene Expression Regulation, EnzymologicGene Expression Regulation, NeoplasticHumansNeoplasm ProteinsPhosphorylationPhosphotransferases (Alcohol Group Acceptor)Signal TransductionCoumarinsEGFR protein, humanErbB ReceptorsNeoplasm ProteinsPhosphotransferases (Alcohol Group Acceptor)bis-coumarinmelanomamigrationpathway analysisphosphokinasesphosphorylationproliferationROStyrosine kinases

Identifiers

PMID35208960
PMCPMC8874408
OpenAlexW4211260689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.