ReviewMolecules (Basel, Switzerland)2022
Antibacterial Effects of Flavonoids and Their Structure-Activity Relationship Study: A Comparative Interpretation.
Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
175 citing papers in PubMed, 421 citations in OpenAlex.
- Natural Product-Based Strategies for Combating Antimicrobial Resistance in ESKAPE Pathogens.Current microbiology · 2026Review
- Oxime Functionalization of Naringin and Naringenin: Tuning Structural, Physicochemical, and Biological Profiling.ACS omega · 2026Article
- Purified Lotus Leaf Flavonoids in Lysozyme-Chitosan Coatings: Effects on Coating Properties and Strawberry Preservation.Foods (Basel, Switzerland) · 2026Article
- Isolation and characterization of Shouchella clausii MJ1G0B, a novel halotolerant bacterium from Madura salt ponds: a putative Valenciaxanthin-like xanthophyll with antioxidant and antibacterial activities.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Regulatory Roles of Kaempferol on the PI3K/AKT/mTOR Signaling Pathway and Associated MicroRNAs in Different Cancer Types.International journal of molecular sciences · 2026Review
- Comparative evaluation of quercetin, rutin, and their nanoparticles: enhanced antimicrobial and antioxidant activities.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Metabolomics Reveals the Dynamic Characteristics of Flavonoids During the Different Developmental Stages ofCurrent issues in molecular biology · 2026Article
- Development of Nanosystems Delivering with Eco-Friendly Antibacterial Agents Composed ofPharmaceutics · 2026Article
- Article
- Therapeutic Potential of Kuwanon G: From Bioactivities to Network-Level Mechanisms.Molecules (Basel, Switzerland) · 2026Review
- Design, Synthesis of Pyridine Based Thiazolidine Derivatives and Investigation of Antimicrobial Activity Targeting Ergosterol Biosynthesis via In Vitro and In Silico Approaches.Chemical biology & drug design · 2026Article
- Enzyme-Assisted Ultrasonic Extraction of Flavonoids fromAntioxidants (Basel, Switzerland) · 2026Article
- 6-methylflavone exerts selective antimycobacterial activity with membrane energetics disruption and demonstrates therapeutic potential againstMicrobiology spectrum · 2026Article
- Therapeutic Applications of Natural Products in Biomedicine and Pharmacotherapy.Life (Basel, Switzerland) · 2026Review
- Evaluation of Plant-Guided Strategies Against Clinical Multidrug-Resistant Pathogens: Preliminary Phytochemical Screening, Antioxidant Capacity, and Antibacterial/Antibiofilm Activity ofAntibiotics (Basel, Switzerland) · 2026Article
- Antibacterial Activity of Quantum-Confined One-Dimensional Titanate Nanofilaments.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- Pharmacological Evaluation of Methanolic Fruit Extract ofFood science & nutrition · 2026Article
- Enzymatic Modification of Flavonoids: Implications for Bioavailability, Bioactivity, and Therapeutic Potential Based on a Systematic Review and Bioinformatics Analysis.Antioxidants (Basel, Switzerland) · 2026Review
- Phytochemistry-Guided Green Synthesis of Antimicrobial Silver Nanoparticles fromInternational journal of molecular sciences · 2026Article
- Modulatory Effects of Polyphenols on Altered Leukocyte Functions in Thromboinflammation and Diabetes Mellitus.International journal of molecular sciences · 2026Review
115 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
According to the latest report released by the World Health Organization, bacterial resistance to well-known and widely available antibacterial drugs has become a significant and severe global health concern and a grim challenge to tackle in order to cure infections associated with multidrug-resistant pathogenic microorganisms efficiently. Consequently, various strategies have been orchestrated to cure the severe complications related to multidrug-resistant bacteria effectively. Some approaches involved the retardation of biofilm formation and multidrug-resistance pumps in bacteria as well as the discovery of new antimicrobial agents demonstrating different mechanisms of action. In this regard, natural products namely alkaloids, terpenoids, steroids, anthraquinone, flavonoids, saponins, tannins, etc., have been suggested to tackle the multidrug-resistant bacterial strains owing to their versatile pharmacological effects. Amongst these, flavonoids, also known as polyphenolic compounds, have been widely evaluated for their antibacterial property due to their tendency to retard the growth of a wide range of pathogenic microorganisms, including multidrug-resistant bacteria. The hydroxylation of C5, C7, C3', and C4'; and geranylation or prenylation at C6 have been extensively studied to increase bacterial inhibition of flavonoids. On the other hand, methoxylation at C3' and C5 has been reported to decrease flavonoids' antibacterial action. Hence, the latest information on the antibacterial activity of flavonoids is summarized in this review, with particular attention to the structure-activity relationship of this broad class of natural compounds to discover safe and potent antibacterial agents as natural products.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.