Evidence map›Paper›PMID 35208924›Full record

ArticleMicroorganisms2022

The Combination of In Vitro Assessment of Stress Tolerance Ability, Autoaggregation, and Vitamin B-Producing Ability for New Probiotic Strain Introduction.

Natalya Yu Khromova, Julia M Epishkina, Boris A Karetkin, Natalia V Khabibulina, Andrey V Beloded, Irina V Shakir, Victor I Panfilov

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 35 citations in OpenAlex.

  1. Impact of lactic acid bacteria andVeterinary and animal science · 2026
    Article
  2. Article
  3. Occurrence and applications of CRISPR-Cas systems in bifidobacteria.Applied and environmental microbiology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Effects ofBiochemistry and biophysics reports · 2023
    Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Natalya Yu KhromovaBiotechnology Department, Mendeleev University of Chemical Technology, 125047 Moscow, Russia.
Julia M EpishkinaBiotechnology Department, Mendeleev University of Chemical Technology, 125047 Moscow, Russia.
Boris A KaretkinBiotechnology Department, Mendeleev University of Chemical Technology, 125047 Moscow, Russia.ORCID 0000-0002-0976-9700
Natalia V KhabibulinaBiotechnology Department, Mendeleev University of Chemical Technology, 125047 Moscow, Russia.
Andrey V BelodedBiotechnology Department, Mendeleev University of Chemical Technology, 125047 Moscow, Russia.ORCID 0000-0002-4425-8068
Irina V ShakirBiotechnology Department, Mendeleev University of Chemical Technology, 125047 Moscow, Russia.
Victor I PanfilovBiotechnology Department, Mendeleev University of Chemical Technology, 125047 Moscow, Russia.
D. Mendeleyev University of Chemical Technology of Russia · RU

Funding

Council for Grants of the President of the Russian Federation МК-1171.2021.5
6 · The paper itself

Abstract

The health benefits of probiotics are beyond doubt. The positive effects of lactobacilli and bifidobacteria on the function of many body systems have been repeatedly proven by various studies. To completely realize the potential of probiotic microorganisms, the strains should be tested by the greatest combination of characteristics that contribute to the wellness of the host. In this work, for the first time, a combined assessment of the probiotic properties and vitamin B-producing potential of various species and strains of bifidobacteria and lactobacilli was carried out. The presence of an additional advantage, such as vitamin-producing ability, can prevent vitamin deficiency both at the level of the consumption of fermented foods, when the enrichment will occur naturally on the spot, and during colonization by these intestinal strains, when synthesis will occur in vivo. To select potential probiotics, the stress tolerance ability of 16 lactic acid bacteria and bifidobacteria strains to low pH values, bile, and proteolytic enzymes, as well as their ability to autoaggregate, were studied under conditions of modeling the gastrointestinal tract in vitro. The ability of the strains to extracellularly accumulate water-soluble B vitamins was evaluated by capillary electrophoresis. Among the tested strains of bifidobacteria,

Indexed as

aggregation abilityBifidobacteriumbiofortificationLactobacillusprobiotic propertiesprobioticsstress tolerance abilitywater-soluble B vitamins

Identifiers

PMID35208924
PMCPMC8879812
OpenAlexW4214674018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.