Evidence map›Paper›PMID 35208856›Full record

ArticleMicroorganisms2022

Identification and Validation of Ikaros (

Alec Steep, Evin Hildebrandt, Hongen Xu, Cari Hearn, Dmitrij Frishman, Masahiro Niikura, John R Dunn, Taejoong Kim, Steven J Conrad, William M Muir and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Alec SteepGenetics Program, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0001-5456-1047
Evin HildebrandtAvian Disease and Oncology Laboratory, US National Poultry Research Center, Agricultural Research Service, USDA, East Lansing, MI 48823, USA.
Hongen XuGenome-Oriented Bioinformatics, Technical University of Munich, D-80333 Munich, Germany.
Cari HearnAvian Disease and Oncology Laboratory, US National Poultry Research Center, Agricultural Research Service, USDA, East Lansing, MI 48823, USA.
Dmitrij FrishmanGenome-Oriented Bioinformatics, Technical University of Munich, D-80333 Munich, Germany.
Masahiro NiikuraFaculty of Health Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
John R DunnEndemic Poultry Viral Diseases Research, US National Poultry Research Center, Agricultural Research Service, USDA, Athens, GA 30605, USA.ORCID 0000-0002-7287-0916
Taejoong KimEndemic Poultry Viral Diseases Research, US National Poultry Research Center, Agricultural Research Service, USDA, Athens, GA 30605, USA.ORCID 0000-0002-5699-998X
Steven J ConradEndemic Poultry Viral Diseases Research, US National Poultry Research Center, Agricultural Research Service, USDA, Athens, GA 30605, USA.
William M MuirDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.
Hans H ChengAvian Disease and Oncology Laboratory, US National Poultry Research Center, Agricultural Research Service, USDA, East Lansing, MI 48823, USA.ORCID 0000-0003-2071-4644
Agricultural Research Service · USTechnical University of Munich · DEMichigan State University · USPurdue University West Lafayette · USSimon Fraser University · CA

Funding

National Institute of Food and Agriculture 2013-67015-21330
6 · The paper itself

Abstract

Marek's disease virus (MDV) is the causative agent for Marek's disease (MD), which is characterized by T-cell lymphomas in chickens. While the viral Meq oncogene is necessary for transformation, it is insufficient, as not every bird infected with virulent MDV goes on to develop a gross tumor. Thus, we postulated that the chicken genome contains cancer driver genes; i.e., ones with somatic mutations that promote tumors, as is the case for most human cancers. To test this hypothesis, MD tumors and matching control tissues were sequenced. Using a custom bioinformatics pipeline, 9 of the 22 tumors analyzed contained one or more somatic mutation in Ikaros (

Indexed as

cancer driver genechickenIkarosMarek’s diseaseMeqrecombinant virussomatic mutation

Identifiers

PMID35208856
PMCPMC8877892
OpenAlexW4211141037

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.