Evidence map›Paper›PMID 35208760›Full record

ArticleMicroorganisms2022

Endogenous Carboxyhemoglobin Level Variation in COVID-19 and Bacterial Sepsis: A Novel Approach?

Bianca-Liana Grigorescu, Irina Săplăcan, Ioana Roxana Bordea, Marius Petrisor, Oana Coman, Claudiu Ion Puiac, Ariana Toncean, Raluca Stefania Fodor

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. Predictive value of NLMR, PLR, and ferritin in relation to SOFA, APACHE II, and SAPS II in sepsis patients.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Iron Porphyrin-mediated Production of Carbon Monoxide from Phenylpyruvic Acid: From Potential Therapeutic and Diagnostic Use to Physiological Implications.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2024
    Article
  6. Is Carboxyhaemoglobin an Effective Bedside Prognostic Tool for Sepsis and Septic Shock Patients?Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2023
    Article
  7. Carboxyhemoglobin Levels in Preterm Neonatal Late-Onset Sepsis: to Predict or not to Predict.Mediterranean journal of hematology and infectious diseases · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Bianca-Liana GrigorescuDepartment of Pathophysiology, University of Medicine, Pharmacology, Sciences and Technology, 540142 Targu-Mures, Romania.
Irina SăplăcanDepartment of Anesthesiology and Intensive Care, Emergency County Hospital, 540136 Targu-Mures, Romania.
Ioana Roxana BordeaDepartment of Oral Rehabilitation, University of Medicine and Pharmacy Iuliu Hatieganu, 400012 Cluj-Napoca, Romania.ORCID 0000-0001-7166-9949
Marius PetrisorDepartment of Simulation Applied in Medicine, University of Medicine, Pharmacology, Sciences and Technology, 540142 Targu-Mures, Romania.
Oana ComanDepartment of Anesthesiology and Intensive Care, Emergency County Hospital, 540136 Targu-Mures, Romania.ORCID 0000-0002-5887-8639
Claudiu Ion PuiacDepartment of Intensive Care, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu-Mures, Romania.
Ariana TonceanDepartment of Anesthesiology and Intensive Care, Emergency County Hospital, 540136 Targu-Mures, Romania.
Raluca Stefania FodorDepartment of Intensive Care, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu-Mures, Romania.
Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș · ROIuliu Hațieganu University of Medicine and Pharmacy · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe increased production of carbon monoxide (CO) in sepsis has been proven, but the blood level variations of carboxyhemoglobin (COHb) as a potential evolutionary parameter of COVID-19 and sepsis/septic shock have yet to be determined. This study aims to evaluate the serum level variation of COHb as a potential evolutionary parameter in COVID-19 critically ill patients and in bacterial sepsis. MATERIALS AND

methodA prospective and observational study was conducted on two groups of patients: the bacterial sepsis group (

resultsD1 of sepsis: statistically significant positive correlations between: COHb values and serum lactate (

conclusionCOHb variation could provide rapid information about the outcome of bacterial sepsis/septic shock, having the advantages of a favorable cost-effectiveness ratio, and availability as a point-of-care test.

Indexed as

carboxyhemoglobinCOVID-19lactateliver dysfunctionsepsis

Identifiers

PMID35208760
PMCPMC8878399
OpenAlexW4210396537

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.