ReviewMedicina (Kaunas, Lithuania)2022
HELLP Syndrome-Holistic Insight into Pathophysiology.
Review in Medicina (Kaunas, Lithuania), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07209748 (The Significance of Soluble CD163 as a Novel Biomarker in the Early Detection and Severity Assessment of HELLP Syndrome), which is not on this map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Significance of Soluble CD163 as a Novel Biomarker in the Early Detection and Severity Assessment of HELLP Syndrome
Who cites it
33 citing papers in PubMed.
- Divergent Risk Factors and Outcomes in Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome and Isolated Preeclampsia.Kidney international reports · 2026Article
- Reversible Neurological Manifestations Preceding Biochemical Deterioration in Postpartum HELLP Syndrome-A Case Report and Literature Review.Journal of clinical hypertension (Greenwich, Conn.) · 2026Review
- Risk Factors and Adverse Perinatal Outcomes in Severe Preeclampsia Complicated by HELLP Syndrome.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Article
- Article
- Shedding light on the function of autophagy in complicated pregnancies.Cell death & disease · 2026Review
- A Case Report of Subcapsular Hepatic Hematoma in a Multiparous Pregnant Woman at 21 Weeks of Gestation: A Fatal Complication of HELLP Syndrome.Case reports in medicine · 2026Article
- Therapeutic plasma exchange in severe postpartum HELLP syndrome: a promising treatment.BMC pregnancy and childbirth · 2025Article
- Hofbauer cell alterations and potential role in the pathophysiology of HELLP syndrome.Human cell · 2025Article
- A Disintegrin and Metalloprotease with Thrombospondin Motif, Member 13, and Von Willebrand Factor in Relation to the Duality of Preeclampsia and HIV Infection.International journal of molecular sciences · 2025Review
- A typical presentation of previable HELLP syndrome: a case report.Journal of surgical case reports · 2025Article
- Local Control of Advanced Breast Cancer-Debate in Multidisciplinary Tumor Board.Journal of clinical medicine · 2025Article
- Health Impacts of Pre-eclampsia: A Comprehensive Analysis of Maternal and Neonatal Outcomes.Medicina (Kaunas, Lithuania) · 2024Observational
- Article
- Investigating hemolysis, elevated liver enzymes and low platelet count in preeclampsia: A case-control study in Ghana.Health science reports · 2024Article
- Circulating extracellular vesicular microRNA signatures in early gestation show an association with subsequent clinical features of pre-eclampsia.Scientific reports · 2024Article
- The Role of Hypertension for Maternal Outcomes of Women with HELLP Syndrome - a Retrospective Study from a Tertiary Obstetric Center.Geburtshilfe und Frauenheilkunde · 2024Article
- The Use and Potential Benefits of N-Acetylcysteine in Non-Acetaminophen Acute Liver Failure: An Etiology-Based Review.Biomedicines · 2024Review
- Assessing the Impact of Organ Failure and Metastases on Quality of Life in Breast Cancer Patients: A Prospective Study Based on Utilizing EORTC QLQ-C30 and EORTC QLQ-BR45 Questionnaires in Romania.Journal of personalized medicine · 2024Article
- Prediction of Subclinical and Clinical Multiple Organ Failure Dysfunction in Breast Cancer Patients-A Review Using AI Tools.Cancers · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HELLP syndrome, also known as the syndrome of hemolysis, elevated liver enzymes, and low platelets, represents a severe pregnancy complication typically associated with hypertension. It is associated with increased risks of adverse complications for both mother and fetus. HELLP occurs in 0.2-0.8% of pregnancies, and, in 70-80% of cases, it coexists with preeclampsia (PE). Both of these conditions show a familial tendency. A woman with a history of HELLP pregnancy is at high risk for developing this entity in subsequent pregnancies. We cannot nominate a single worldwide genetic cause for the increased risk of HELLP. Combinations of multiple gene variants, each with a moderate risk, with concurrent maternal and environmental factors are thought to be the etiological mechanisms. This review highlights the significant role of understanding the underlying pathophysiological mechanism of HELLP syndrome. A better knowledge of the disease's course supports early detection, an accurate diagnosis, and proper management of this life-threatening condition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.