ArticleMicromachines2022
A Narrow Straight Microchannel Array for Analysis of Transiting Speed of Floating Cancer Cells.
Article in Micromachines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- Continuous Size-Based Particle Separation Using Inertial Force and Deterministic Lateral Displacement.Micromachines · 2026Article
- Characterization of Shrink Film Properties for Rapid Microfluidics Lab-on-Chip Fabrication.Micromachines · 2024Article
- Editorial for the Special Issue on Microfluidics and Lab-on-a-Chip Applications for Biosensing.Micromachines · 2022Article
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Authors and funding
4 authors.
Funding
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Abstract
Investigating floating cells along a narrow microchannel (e.g., a blood vessel) for their transiting speeds and the corresponding roles of cell physical properties can deepen our understanding of circulating tumor cells (CTCs) metastasis via blood vessels. Many existing studies focus on the cell transiting process in blood vessel-like microchannels; further analytical studies are desired to summarize behaviors of the floating cell movement under different conditions. In this work, we perform a theoretical analysis to establish a relation between the transiting speed and key cell physical properties. We also conduct computational fluid dynamics simulation and microfluidic experiments to verify the theoretical model. This work reveals key cell physical properties and the channel configurations determining the transiting speed. The reported model can be applied to other works with various dimensions of microchannels as a more general way to evaluate the cancer cell metastasis ability with microfluidics.
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Registered trials
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