Evidence map›Paper›PMID 35208265›Full record

ArticleMetabolites2022

Plasma Oxylipin Profile Discriminates Ethnicities in Subjects with Non-Alcoholic Steatohepatitis: An Exploratory Analysis.

Tagreed A Mazi, Kamil Borkowski, Oliver Fiehn, Christopher L Bowlus, Souvik Sarkar, Karen Matsukuma, Mohamed R Ali, Dorothy A Kieffer, Yu-Jui Y Wan, Kimber L Stanhope and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Tagreed A MaziDepartment of Nutrition, University of California Davis, Davis, CA 95616, USA.ORCID 0000-0002-1250-7234
Kamil BorkowskiWest Coast Metabolomic Center, Genome Center, University of California Davis, Davis, CA 95616, USA.
Oliver FiehnWest Coast Metabolomic Center, Genome Center, University of California Davis, Davis, CA 95616, USA.ORCID 0000-0002-6261-8928
Christopher L BowlusDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of California Davis, Sacramento, CA 95817, USA.
Souvik SarkarDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of California Davis, Sacramento, CA 95817, USA.
Karen MatsukumaDepartment of Pathology and Laboratory Medicine, University of California Davis, Sacramento, CA 95817, USA.
Mohamed R AliDepartment of Surgery, University of California Davis, Sacramento, CA 95817, USA.
Dorothy A KiefferDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of California Davis, Sacramento, CA 95817, USA.
Yu-Jui Y WanDepartment of Pathology and Laboratory Medicine, University of California Davis, Sacramento, CA 95817, USA.ORCID 0000-0003-2243-7759
Kimber L StanhopeDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA.ORCID 0000-0002-2474-0914
Peter J HavelDepartment of Nutrition, University of California Davis, Davis, CA 95616, USA.
John W NewmanDepartment of Nutrition, University of California Davis, Davis, CA 95616, USA.
Valentina MediciDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of California Davis, Sacramento, CA 95817, USA.ORCID 0000-0001-5438-284X
University of California, Davis · USKing Saud University · SAUnited States Department of Agriculture · US

Funding

West Coast Central Comprehensive Metabolomics Resource Core (WC3MRC)U24DK097154 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FIEHN, OLIVER · 2012 to 2017
$9.9M
Epigenetic regulation of Wilson DiseaseR01DK104770 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MEDICI, VALENTINA · 2016 to 2020
$1.8M
Fatty acid sources of fructose and HFCS-induced postprandial hypertriglyceridemiaR01HL107256 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HAVEL, PETER J, SCHWARZ, JEAN-MARC · 2011 to 2014
$1.5M
NIH HHS 1R01 HL09133NIH HHS 1R01 HL107256NIH HHS R01 DK104770NIH HHS U24 DK097154United States Department of Agriculture 2032-51530-025-00D
6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a common liver pathology that includes steatosis, or non-alcoholic fatty liver (NAFL), and non-alcoholic steatohepatitis (NASH). Without a clear pathophysiological mechanism, it affects Hispanics disproportionately compared to other ethnicities. Polyunsaturated fatty acids (PUFAs) and inflammatory lipid mediators including oxylipin (OXL) and endocannabinoid (eCB) are altered in NAFLD and thought to contribute to its pathogenesis. However, the existence of ethnicity-related differences is not clear. We employed targeted lipidomic profiling for plasma PUFAs, non-esterified OXLs and eCBs in White Hispanics (HIS,

Indexed as

arachidonic acidCaucasiancyclooxygenasesendocannabinoidsethnicityHispaniclipoxygenasesnon-alcoholic steatohepatitisoxylipinspolyunsaturated fatty acidssoluble epoxide hydrolases

Identifiers

PMID35208265
PMCPMC8875408
OpenAlexW4220953533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.