ReviewMetabolites2022
Iron Metabolism in Normal and Pathological Pregnancies and Fetal Consequences.
Review in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Ferritin as a diagnostic point-of-care marker in iron deficiency anemia: a narrative review and clinical implications.Annals of translational medicine · 2026Review
- Assessment of Nutritional and Nonnutritional Correlates of Anemia in Pregnancy: A Hospital-Based Cross-Sectional Study for Public Health Interventions in the Bono East Region of Ghana.Health science reports · 2026Article
- Placental iron transport under maternal stress: a missing link in foetal programming and mental health.EBioMedicine · 2026Article
- Compliance to iron folic acid supplementation and its associated factors among postpartum mothers of Bharatpur, Nepal: a cross-sectional study.BMJ public health · 2026Article
- Article
- Iron deficiency anemia in pregnancy and related complications with specific insight in Rivers State, Nigeria: a narrative review.Annals of medicine and surgery (2012) · 2025Review
- p53-mediated suppression of the SLC7 A11/GPX4 signaling pathway promotes trophoblast ferroptosis in preeclampsia.BMC biology · 2025Article
- Maternal iron nutrition during pregnancy and fetal intrauterine growth.Nutrition journal · 2024Article
- Association between Adiposity and Iron Status in Women of Reproductive Age: Data from the UK National Diet and Nutrition Survey (NDNS) 2008-2019.The Journal of nutrition · 2024Article
- Physiologically based trimester-specific serum ferritin thresholds for iron deficiency in US pregnant women.Blood advances · 2024Article
- Oxidative Stress, Lipid Peroxidation and Ferroptosis Are Major Pathophysiological Signatures in the Placental Tissue of Women with Late-Onset Preeclampsia.Antioxidants (Basel, Switzerland) · 2024Article
- Unraveling the Role of Maternal Serum Ferritin Levels in Preterm Delivery: A Comprehensive Review.Cureus · 2024Review
- Molecular insights into placental iron transfer mechanisms and maternofetal regulation.Archives of gynecology and obstetrics · 2024Review
- Article
- The Ferritin, Hepcidin and Cytokines Link in the Diagnoses of Iron Deficiency Anaemia during Pregnancy: A Review.International journal of molecular sciences · 2023Review
- Effect of Adherence to the Mediterranean Diet on Maternal Iron Related Biochemical Parameters during Pregnancy and Gestational Weight Gain.Life (Basel, Switzerland) · 2023Article
- Hypophosphataemia risk associated with ferric carboxymaltose in heart failure: A pooled analysis of clinical trials.ESC heart failure · 2023Article
- The Placentas of Women Who Suffer an Episode of Psychosis during Pregnancy Have Increased Lipid Peroxidation with Evidence of Ferroptosis.Biomolecules · 2023Article
- Maternal heme-enriched diet promotes a gut pro-oxidative status associated with microbiota alteration, gut leakiness and glucose intolerance in mice offspring.Redox biology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron is required for energy production, DNA synthesis, and cell proliferation, mainly as a component of the prosthetic group in hemoproteins and as part of iron-sulfur clusters. Iron is also a critical component of hemoglobin and plays an important role in oxygen delivery. Imbalances in iron metabolism negatively affect these vital functions. As the crucial barrier between the fetus and the mother, the placenta plays a pivotal role in iron metabolism during pregnancy. Iron deficiency affects 1.2 billion individuals worldwide. Pregnant women are at high risk of developing or worsening iron deficiency. On the contrary, in frequent hemoglobin diseases, such as sickle-cell disease and thalassemia, iron overload is observed. Both iron deficiency and iron overload can affect neonatal development. This review aims to provide an update on our current knowledge on iron and heme metabolism in normal and pathological pregnancies. The main molecular actors in human placental iron metabolism are described, focusing on the impact of iron deficiency and hemoglobin diseases on the placenta, together with normal metabolism. Then, we discuss data concerning iron metabolism in frequent pathological pregnancies to complete the picture, focusing on the most frequent diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.