Evidence map›Paper›PMID 35208178›Full record

ArticleMetabolites2022

Photobiomodulation at Different Wavelengths Boosts Mitochondrial Redox Metabolism and Hemoglobin Oxygenation:

Tyrell Pruitt, Caroline Carter, Xinlong Wang, Anqi Wu, Hanli Liu

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07736092 (Impact of Perioperative Transcranial Photobiomodulation on Delayed Neurocognitive Recovery in Older Patients After Surgery), which is not on this map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07736092 narecruitingnot on this mapstarted 2026, after this paper: background citation

Impact of Perioperative Transcranial Photobiomodulation on Delayed Neurocognitive Recovery in Older Patients After Surgery: a Randomized, Double-blind, Pseudo-modulation-controlled Preliminary Clinical Trial

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2027Enrolled130ConditionsOlder Adults, Surgery, Transcranial Photobiomodulation, Delayed Neurocognitive RecoveryArmsTranscranial photobiomodulation therapy, Transcranial pseudo-photobiomodulation
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tyrell PruittDepartment of Bioengineering, University of Texas at Arlington, 500 UTA Blvd, Arlington, TX 76019, USA.
Caroline CarterDepartment of Bioengineering, University of Texas at Arlington, 500 UTA Blvd, Arlington, TX 76019, USA.
Xinlong WangDepartment of Bioengineering, University of Texas at Arlington, 500 UTA Blvd, Arlington, TX 76019, USA.
Anqi WuDepartment of Bioengineering, University of Texas at Arlington, 500 UTA Blvd, Arlington, TX 76019, USA.
Hanli LiuDepartment of Bioengineering, University of Texas at Arlington, 500 UTA Blvd, Arlington, TX 76019, USA.ORCID 0000-0002-9312-5691

Funding

Novel Neuromodulation by Transcranial Infrared Brain Stimulation with ImagingRF1MH114285 · NIMH · UNIVERSITY OF TEXAS ARLINGTON · PI GONZALEZ-LIMA, FRANCISCO, LIU, HANLI · 2017 to 2017
$2.9M
NIH HHS NIH RF1MH114285NIMH NIH HHS RF1 MH114285
6 · The paper itself

Abstract

Our group previously examined 8 min photobiomodulation (PBM) by 1064 nm laser on the human forearm in vivo to determine its significant effects on vascular hemodynamics and cytochrome c oxidase redox activity. Since PBM uses a wide array of wavelengths, in this paper, we investigated (i) whether different wavelengths of lasers induced different PBM effects, and (ii) if a light-emitting diode (LED) at a similar wavelength to a laser could induce similar PBM effects. A broadband near-infrared spectroscopy (bbNIRS) system was utilized to assess concentration changes in oxygenated hemoglobin (Δ[HbO]) and oxidized cytochrome c oxidase (Δ[oxCCO]) during and after PBM with lasers at 800 nm, 850 nm, and 1064 nm, as well as a LED at 810 nm. Two groups of 10 healthy participants were measured before, during, and after active and sham PBM on their forearms. All results were tested for significance using repeated measures ANOVA. Our results showed that (i) lasers at all three wavelengths enabled significant increases in Δ[HbO] and Δ[oxCCO] of the human forearm while the 1064 nm laser sustained the increases longer, and that (ii) the 810-nm LED with a moderate irradiance (≈135 mW/cm

Indexed as

broadband near-infrared spectroscopycytochrome c oxidaselight-emitting diodesoxygenated hemoglobin concentrationphotobiomodulationredox metabolism

Identifiers

PMID35208178
PMCPMC8880116

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.