ArticleMaterials (Basel, Switzerland)2022
3D-Printed HA-Based Scaffolds for Bone Regeneration: Microporosity, Osteoconduction and Osteoclastic Resorption.
Article in Materials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Design of 3D-printed hydroxyapatite intervertebral fusion cages in a patient specific framework.Medical & biological engineering & computing · 2026Article
- Enhancing the osteogenic potential of 3D-printed polycaprolactone/hydroxyapatite composite scaffolds via in-situ ZIF-8 surface modification.Journal of materials science. Materials in medicine · 2026Article
- 3D-Printed Bone Spacers with Dual-Phase Structure: A Comparison of Biogenic and Commercial Hydroxyapatite for Potential Treatment of Bone Defects.ACS applied bio materials · 2026Article
- Bone-Healing Enhancement Using Particulate Biomaterials and Fibrin-Based Compounds: A Narrative Literature Review of Evidence in Animal Models.Materials (Basel, Switzerland) · 2026Review
- Early Cell Adhesion of Periodontal Ligament Stem Cells on 3D Printed Polylactic Acid/Hydroxyapatite Scaffolds: An In Vitro Study.Polymers · 2025Article
- Biological Characterization of 3D-Printed, Sintered Hydroxyapatite Scaffolds Obtained by Fused Filament Fabrication: An In Vitro Study.Journal of functional biomaterials · 2025Article
- Global Research Trends and Hotspots in Fracture Nonunion and Delayed Union: A 2-Decade Bibliometric Analysis.Indian journal of orthopaedics · 2025Article
- Developments in Alloplastic Bone Grafts and Barrier Membrane Biomaterials for Periodontal Guided Tissue and Bone Regeneration Therapy.International journal of molecular sciences · 2024Review
- Influence of physicochemical characteristics of calcium phosphate-based biomaterials in cranio-maxillofacial bone regeneration. A systematic literature review and meta-analysis of preclinical models.Materials today. Bio · 2024Article
- Functionalization of Ceramic Scaffolds with Exosomes from Bone Marrow Mesenchymal Stromal Cells for Bone Tissue Engineering.International journal of molecular sciences · 2024Article
- 3D printed bioabsorbable composite scaffolds of poly (lactic acid)-tricalcium phosphate-ceria with osteogenic property for bone regeneration.Biomaterials and biosystems · 2024Article
- Enhanced bone regeneration in rat calvarial defects through BMP2 release from engineered poly(ethylene glycol) hydrogels.Scientific reports · 2024Article
- Three-Dimensional Printed Hydroxyapatite Bone Substitutes Designed by a Novel Periodic Minimal Surface Algorithm Are Highly Osteoconductive.3D printing and additive manufacturing · 2023Article
- Triply Periodic Minimal Surface-Based Scaffolds for Bone Tissue Engineering: A Mechanical,Tissue engineering. Part A · 2023Article
- Reconstruction of Load-Bearing Segmental Bone Defects Using Carbonate Apatite Honeycomb Blocks.ACS materials Au · 2023Article
- Osteoconductivity of bone substitutes with filament-based microarchitectures: Influence of directionality, filament dimension, and distance.International journal of bioprinting · 2023Article
- Dual-Scale Porosity Alumina Structures Using Ceramic/Camphene Suspensions Containing Polymer Microspheres.Materials (Basel, Switzerland) · 2022Article
- The Effect of Low-Temperature Thermal Processing on Bovine Hydroxyapatite Bone Substitutes, toward Bone Cell Interaction and Differentiation.Materials (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Additive manufacturing enables the realization of the macro- and microarchitecture of bone substitutes. The macroarchitecture is determined by the bone defect and its shape makes the implant patient specific. The preset distribution of the 3D-printed material in the macroarchitecture defines the microarchitecture. At the lower scale, the nanoarchitecture of 3D-printed scaffolds is dependent on the post-processing methodology such as the sintering temperature. However, the role of microarchitecture and nanoarchitecture of scaffolds for osteoconduction is still elusive. To address these aspects in more detail, we produced lithography-based osteoconductive scaffolds from hydroxyapatite (HA) of identical macro- and microarchitecture and varied their nanoarchitecture, such as microporosity, by increasing the maximum sintering temperatures from 1100 to 1400 °C. The different scaffold types were characterized for microporosity, compression strength, and nanoarchitecture. The in vivo results, based on a rabbit calvarial defect model showed that bony ingrowth, as a measure of osteoconduction, was independent from scaffold's microporosity. The same applies to in vitro osteoclastic resorbability, since on all tested scaffold types, osteoclasts formed on their surfaces and resorption pits upon exposure to mature osteoclasts were visible. Thus, for wide-open porous HA-based scaffolds, a low degree of microporosity and high mechanical strength yield optimal osteoconduction and creeping substitution. Based on our study, non-unions, the major complication during demanding bone regeneration procedures, could be prevented.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.