ArticleJournal of personalized medicine2022
Lipoprotein(a), Immune Cells and Cardiovascular Outcomes in Patients with Premature Coronary Heart Disease.
Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Association of Monocyte Subsets with Carotid Artery Stenosis Severity.Medicina (Kaunas, Lithuania) · 2026Article
- Correlation Analysis of the New Inflammatory Composite Index with the Degree of Coronary Artery Lesions in Elderly Patients.Clinical interventions in aging · 2026Article
- Exploring biomarkers related to coagulation and immunity in myocardial infarction based on bioinformatics.Scientific reports · 2025Article
- Interpretable machine learning analysis of immunoinflammatory biomarkers for predicting CHD among NAFLD patients.Cardiovascular diabetology · 2025Article
- Lipoprotein(a) and Blood Monocytes as Factors for Progression of Carotid Atherosclerosis in Patients with Premature Coronary Heart Disease.Diseases (Basel, Switzerland) · 2025Article
- Association between the atherogenic index of plasma and major adverse cardiovascular events in patients with premature coronary artery disease.European journal of medical research · 2025Article
- Downregulation of microRNA‑221‑3p promotes angiogenesis of lipoprotein(a)‑injured endothelial progenitor cells by targeting silent information regulator 1 to activate the RAF/MEK/ERK signaling pathway.Molecular medicine reports · 2024Article
- Comparative Analysis of Atherogenic Lipoproteins L5 and Lp(a) in Atherosclerotic Cardiovascular Disease.Current atherosclerosis reports · 2024Review
- Novel lipid biomarkers and ratios as risk predictors for premature coronary artery disease: A retrospective analysis of 2952 patients.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- The Concentration of PCSK9-Lp(a) Complexes and the Level of Blood Monocytes in Males with Coronary Atherosclerosis.Journal of personalized medicine · 2023Article
- Epidemiology of atherosclerotic cardiovascular disease in polygenic hypercholesterolemia with or without high lipoprotein(a) levels.Frontiers in cardiovascular medicine · 2023Article
- Article
- Neutrophil Count as Atrioventricular Block (AVB) Predictor following Pediatric Heart Surgery.International journal of molecular sciences · 2022Article
- Basic Research in Atherosclerosis: Technologies of Personalized Medicine.Journal of personalized medicine · 2022Article
- Lymphocyte-to-Monocyte Ratio Is Independently Associated with Progressive Infarction in Patients with Acute Ischemic Stroke.BioMed research international · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The detection of lipoprotein(a) [Lp(a)] in the artery wall at the stage of lipid-bands formation may indicate that it participates in the atherosclerosis local nonspecific inflammatory process. Innate immune cells are involved in atherogenesis, with monocytes playing a major role in the initiation of atherosclerosis, while neutrophils can contribute to plaque destabilization. This work studies the relationship between Lp(a), immune blood cells and major adverse cardiovascular events (MACE) in patients with the early manifestation of coronary heart disease (CHD). The study included 200 patients with chronic CHD, manifested up to the age of 55 in men and 60 in women. An increased Lp(a) concentration [hyperLp(a)] was shown to predict cardiovascular events in patients with premature CHD with long-term follow-up. According to the logistic regression analysis results, an increase in the monocyte count with OR = 4.58 (95% CI 1.04-20.06) or lymphocyte-to-monocyte ratio with OR = 0.82 (0.68-0.99), (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.