Evidence map›Paper›PMID 35207738›Full record

ArticleJournal of personalized medicine2022

Short-Term Efficacy of Transcranial Focused Ultrasound to the Hippocampus in Alzheimer's Disease: A Preliminary Study.

Hyeonseok Jeong, In-Uk Song, Yong-An Chung, Jong-Sik Park, Seung-Hee Na, Jooyeon Jamie Im, Marom Bikson, Wonhye Lee, Seung-Schik Yoo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 5 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 5 syntheses or guidelines pooled it, 48 citations in OpenAlex.

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  19. The Associative Thalamus: A Switchboard for Cortical Operations and a Promising Target for Schizophrenia.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Hyeonseok JeongDepartment of Nuclear Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 21431, Korea.
In-Uk SongDepartment of Neurology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 21431, Korea.
Yong-An ChungDepartment of Nuclear Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 21431, Korea.
Jong-Sik ParkDepartment of Neurology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 21431, Korea.
Seung-Hee NaDepartment of Neurology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 21431, Korea.ORCID 0000-0001-8578-8578
Jooyeon Jamie ImDepartment of Nuclear Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 21431, Korea.
Marom BiksonDepartment of Biomedical Engineering, The City College of New York, New York, NY 10031, USA.
Wonhye LeeDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Seung-Schik YooDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
St. Mary's Hospital · USThe Catholic University of Korea Incheon St. Mary's Hospital · KRBrigham and Women's Hospital · USCity College of New York · US

Funding

Korea Health Industry Development Institute (KHIDI) and Korea Dementia Research Center (KDRC) HU21C0081National Research Foundation of Korea 2020R1C1C1007254Neurosona Co., Ltd. N/A
6 · The paper itself

Abstract

Preclinical studies have suggested that low-intensity transcranial focused ultrasound (tFUS) may have therapeutic potential for Alzheimer's disease (AD) by opening the blood-brain barrier (BBB), reducing amyloid pathology, and improving cognition. This study investigated the effects of tFUS on BBB opening, regional cerebral metabolic rate of glucose (rCMRglu), and cognitive function in AD patients. Eight patients with AD received image-guided tFUS to the right hippocampus immediately after intravenous injection of microbubble ultrasound contrast agents. Patients completed magnetic resonance imaging (MRI),

Indexed as

Alzheimer’s diseaseblood–brain barriercognitionregional cerebral metabolic rate of glucosetranscranial focused ultrasound

Identifiers

PMID35207738
PMCPMC8878180
OpenAlexW4211111758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.