Evidence map›Paper›PMID 35207726›Full record

ArticleJournal of personalized medicine2022

Immune Response and Lipid Metabolism Gene Polymorphisms Are Associated with the Risk of Obesity in Middle-Aged and Elderly Patients.

Anastasia Ponasenko, Maxim Sinitsky, Varvara Minina, Anna Vesnina, Maria Khutornaya, Alexander Prosekov, Olga Barbarash

Abstract read
In one paragraph

Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Systematic Review ofInternational journal of molecular sciences · 2024
    Pooled it
  2. Efficacy of Dapagliflozin Combined with Lifestyle Intervention in Obesity Control.Computational and mathematical methods in medicine · 2022
    Trial
  3. Article
  4. Article
  5. Article
  6. Effect of Semaglutide and Empagliflozin on Pulmonary Structure and Proteomics in Obese Mice.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anastasia PonasenkoLaboratory of Genome Medicine, Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russia.
Maxim SinitskyLaboratory of Genome Medicine, Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russia.ORCID 0000-0002-4824-2418
Varvara MininaDepartment of Genetic and Fundamental Medicine, Kemerovo State University, 650000 Kemerovo, Russia.ORCID 0000-0003-3485-9123
Anna VesninaDepartment of Bionanotechnology, Kemerovo State University, 650000 Kemerovo, Russia.ORCID 0000-0002-4552-7418
Maria KhutornayaLaboratory of Genome Medicine, Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russia.
Alexander ProsekovDepartment of Bionanotechnology, Kemerovo State University, 650000 Kemerovo, Russia.ORCID 0000-0002-5630-3196
Olga BarbarashResearch Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russia.

Funding

Complex Program of Fundamental Research of the Siberian Branch of the Russian Academy of Sciences within the framework of the fundamental research project of Research Institute for Complex Issues of Cardiovascular Diseases 0554-2019-0003Russian State Task N0352-2019-0011
6 · The paper itself

Abstract

More than two billion people around the world are overweight or obese. Even in apparently healthy people, obesity has a potent effect on their quality of life. Experimental data indicate the role of infectious agents in systemic inflammation, revealing a correlation between the dietary habits of people with obesity and the level of systemic inflammation mediators, serum lipid concentration, and hormonal and immune status. This study aimed to determine the association of immune response and lipid metabolism gene polymorphisms with the risk of obesity. This study included 560 Caucasian participants living in Western Siberia (Russian Federation). A total of 52 polymorphic sites in 20 genes were analyzed using the 5' TaqMan nuclease assay. Four risk-associated polymorphic variants were discovered-two variants in immune response genes (

Indexed as

genetic polymorphismimmunityinflammationlipid metabolismobesity

Identifiers

PMID35207726
PMCPMC8879873

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.