Evidence map›Paper›PMID 35207712›Full record

ArticleJournal of personalized medicine2022

Transdiagnostic Symptom Subtypes to Predict Response to Therapeutic Transcranial Magnetic Stimulation in Major Depressive Disorder and Posttraumatic Stress Disorder.

Camila Cosmo, Yosef A Berlow, Katherine A Grisanzio, Scott L Fleming, Abdullah P Rashed Ahmed, McKenna C Brennan, Linda L Carpenter, Noah S Philip

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Camila CosmoDepartment of Psychiatry and Human Behavior, The Warren Alpert Medical School, Brown University, Providence, RI 02912, USA.ORCID 0000-0002-5874-7188
Yosef A BerlowDepartment of Psychiatry and Human Behavior, The Warren Alpert Medical School, Brown University, Providence, RI 02912, USA.
Katherine A GrisanzioCenter for Brain Science, Department of Psychology, Harvard University, Cambridge, MA 02138, USA.
Scott L FlemingDepartment of Biomedical Data Science, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-6047-7877
Abdullah P Rashed AhmedDepartment of Neuroscience, Brown University, Providence, RI 02912, USA.
McKenna C BrennanVA RR&D Center for Neurorestoration and Neurotechnology, VA Providence Healthcare System, Providence, RI 02908, USA.
Linda L CarpenterDepartment of Psychiatry and Human Behavior, The Warren Alpert Medical School, Brown University, Providence, RI 02912, USA.ORCID 0000-0002-9651-3307
Noah S PhilipDepartment of Psychiatry and Human Behavior, The Warren Alpert Medical School, Brown University, Providence, RI 02912, USA.ORCID 0000-0002-4889-8775

Funding

Neuroimaging and Neuromodulation CoreP20GM130452 · NIGMS · BUTLER HOSPITAL (PROVIDENCE, RI) · PI GREENBERG, BENJAMIN D · 2019 to 2023
$11.3M
Mechanistic circuit markers of transcranial magnetic stimulation outcomes in pharmacoresistant depressionR01MH120126 · NIMH · STANFORD UNIVERSITY · PI WILLIAMS, LEANNE · 2019 to 2023
$3.4M
Promoting Research Training During Psychiatry ResidencyR25MH101076 · NIMH · BROWN UNIVERSITY · PI AUDREY TYRKA · 2013 to 2026
$2.8M
Combined Transcranial Magnetic Stimulation and Brief Cognitive Therapy to Reduce Veteran SuicideI01HX002572 · VA · PROVIDENCE VA MEDICAL CENTER · PI PHILIP, NOAH STEPHEN, PRIMACK, JENNIFER MARIE · 2019 to 2024
–
Combined Transcranial Direct Current Stimulation and Virtual Reality for PTSDI01RX002450 · VA · PROVIDENCE VA MEDICAL CENTER · PI PHILIP, NOAH STEPHEN · 2018 to 2022
–
VA RR&D Center for Neurorestoration and NeurotechnologyI50RX002864 · VA · PROVIDENCE VA MEDICAL CENTER · PI BENJAMIN D GREENBERG, LEIGH R HOCHBERG · 2018 to 2026
–
HSRD VA I01 HX002572National Institute of Health 5T32LM012409-03National Science Foundation DGE1745303NIGMS NIH HHS P20 GM130452NIMH NIH HHS R01 MH120126NIMH NIH HHS R25 MH101076RRD VA I01 RX002450RRD VA I50 RX002864
6 · The paper itself

Abstract

The diagnostic categories in psychiatry often encompass heterogeneous symptom profiles associated with differences in the underlying etiology, pathogenesis and prognosis. Prior work demonstrated that some of this heterogeneity can be quantified though dimensional analysis of the Depression Anxiety Stress Scale (DASS), yielding unique transdiagnostic symptom subtypes. This study investigated whether classifying patients according to these symptom profiles would have prognostic value for the treatment response to therapeutic transcranial magnetic stimulation (TMS) in comorbid major depressive disorder (MDD) and posttraumatic stress disorder (PTSD). A linear discriminant model was constructed using a simulation dataset to classify 35 participants into one of the following six pre-defined symptom profiles: Normative Mood, Tension, Anxious Arousal, Generalized Anxiety, Anhedonia and Melancholia. Clinical outcomes with TMS across MDD and PTSD were assessed. All six symptom profiles were present. After TMS, participants with anxious arousal were less likely to achieve MDD remission compared to other subtypes (FET, odds ratio 0.16,

Indexed as

anxious arousalbiomarkerlinear discriminant analysissymptom subtypesTMStransdiagnostic

Identifiers

PMID35207712
PMCPMC8874724

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.