Evidence map›Paper›PMID 35207710›Full record

ArticleJournal of personalized medicine2022

Retrospective Analysis of Patients with Gynaecological Uterine Sarcomas in a Tertiary Hospital.

Maria Ruiz-Minaya, Elsa Mendizabal-Vicente, Wenceslao Vasquez-Jimenez, Laura Perez-Burrel, Irene Aracil-Moreno, Carolina Agra-Pujol, Mireia Bernal-Claverol, Beatriz L Martínez-Bernal, Mercedes Muñoz-Fernández, Melanie Morote-Gonzalez and 3 more

Abstract read
In one paragraph

Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maria Ruiz-MinayaDepartment of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.
Elsa Mendizabal-VicenteDepartment of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.
Wenceslao Vasquez-JimenezPeritoneal Carcinomatosis, Sarcomas and Complex Pelvis Unit, General Surgery and Digestive System Service, Gregorio Marañón General Hospital, 28009 Madrid, Spain.
Laura Perez-BurrelDepartment of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.
Irene Aracil-MorenoDepartment of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0003-1009-8446
Carolina Agra-PujolPathological Anatomy Service, Gregorio Marañón General Hospital, 28009 Madrid, Spain.
Mireia Bernal-ClaverolDepartment of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.
Beatriz L Martínez-BernalPathological Anatomy Service, Gregorio Marañón General Hospital, 28009 Madrid, Spain.
Mercedes Muñoz-FernándezRadiotherapy Oncology Service, Gregorio Marañón General Hospital, 28009 Madrid, Spain.
Melanie Morote-GonzalezPeritoneal Carcinomatosis, Sarcomas and Complex Pelvis Unit, General Surgery and Digestive System Service, Gregorio Marañón General Hospital, 28009 Madrid, Spain.
Miguel A OrtegaDepartment of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, 28801 Madrid, Spain.ORCID 0000-0003-2588-1708
Santiago Lizarraga-BonelliDepartment of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.
Juan A De Leon-LuisDepartment of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0002-6320-2668

Funding

Instituto de Salud Carlos III PI18/00912
6 · The paper itself

Abstract

Uterine sarcomas are rare and heterogeneous malignancies accounting for 1% to 3% of all gynaecological tumours. There are many histological subtypes recognised, including leiomyosarcomas, endometrial stromal sarcoma, and uterine carcinosarcoma, although the latest has been recently discarded in this group. Despite its low incidence, these types of cancer currently entail multiple challenges, either in diagnostics or clinical management, with a poor prognosis associated. The present work aimed to complete a comparative analysis of the different histological subtypes based on the clinicopathological characteristics of our population, the therapeutic characteristics, and associated prognosis in 161 patients treated in our centre during the period between 1985 and 2020. Moreover, a systematic review grouped a total of 2211 patients with a diagnosis of uterine sarcoma from 19 articles published in 16 countries from 2002 to 2021 was performed, all with retrospective analyses. Our results showed that apart from uterine carcinosarcoma, leiomyosarcoma is the most frequent subtype of uterine sarcoma, with unique clinical, demographic, and survival parameters. To our knowledge, this is the first systematic review conducted in this field and, thus, it shows the difficulties of collecting a significant number of patients per year, a valid reason why multicentre or national registries are recommended to allow a more exhaustive analysis of this pathology.

Indexed as

comparative analysisgynaecological malignanciessystematic reviewuterine sarcoma

Identifiers

PMID35207710
PMCPMC8880358

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.