Evidence map›Paper›PMID 35207658›Full record

ReviewJournal of personalized medicine2022

The Paris System for Reporting Urinary Cytology: A Meta-Analysis.

Ilias P Nikas, Svenja Seide, Tanja Proctor, Zoi Kleinaki, Maria Kleinaki, Jordan P Reynolds

Abstract readReview
In one paragraph

Review in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  19. Bladder cancer.Nature reviews. Disease primers · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ilias P NikasSchool of Medicine, European University Cyprus, Nicosia 2404, Cyprus.ORCID 0000-0001-8625-2556
Svenja SeideInstitute of Medical Biometry, University of Heidelberg, 69120 Heidelberg, Germany.
Tanja ProctorInstitute of Medical Biometry, University of Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0003-3760-9971
Zoi KleinakiSchool of Medicine, European University Cyprus, Nicosia 2404, Cyprus.ORCID 0000-0002-0658-1876
Maria KleinakiSchool of Medicine, European University Cyprus, Nicosia 2404, Cyprus.
Jordan P ReynoldsDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL 32256, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Paris System (TPS) for Reporting Urinary Cytology is a standardized, evidence-based reporting system, comprising seven diagnostic categories: nondiagnostic, negative for high-grade urothelial carcinoma (NHGUC), atypical urothelial cells (AUC), suspicious for high-grade urothelial carcinoma (SHGUC), HGUC, low-grade urothelial neoplasm (LGUN), and other malignancies. This study aimed to calculate the pooled risk of high-grade malignancy (ROHM) of each category and demonstrate the diagnostic accuracy of urine cytology reported with TPS. Four databases (PubMed, Embase, Scopus, Web of Science) were searched. Specific inclusion and exclusion criteria were applied, while data were extracted and analyzed both qualitatively and quantitatively. The pooled ROHM was 17.70% for the nondiagnostic category (95% CI, 0.0650; 0.3997), 13.04% for the NHGUC (95% CI, 0.0932; 0.1796), 38.65% for the AUC (95% CI, 0.3042; 0.4759), 12.45% for the LGUN (95% CI, 0.0431; 0.3101), 76.89 for the SHGUC (95% CI, 0.7063; 0.8216), and 91.79% for the HGUC and other malignancies (95% CI, 0.8722; 0.9482). A summary ROC curve was created and the Area Under the Curve (AUC) was 0.849, while the pooled sensitivity was 0.669 (95% CI, 0.589; 0.741) and false-positive rate was 0.101 (95% CI, 0.063; 0.158). In addition, the pooled DOR of the included studies was 21.258 (95% CI, 14.336; 31.522). TPS assigns each sample into a diagnostic category linked with a specific ROHM, guiding clinical management.

Indexed as

bladder cancercytopathologydiagnostic accuracypathologyrisk of high-grade malignancy (ROHM)sensitivity and specificitytumorurineurothelial carcinomaurothelial neoplasia

Identifiers

PMID35207658
PMCPMC8874476

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.