Evidence map›Paper›PMID 35207649›Full record

ArticleJournal of personalized medicine2022

Assessment of a Manual Method versus an Automated, Probability-Based Algorithm to Identify Patients at High Risk for Pharmacogenomic Adverse Drug Outcomes in a University-Based Health Insurance Program.

Kendra J Grande, Rachel Dalton, Nicolas A Moyer, Meghan J Arwood, Khoa A Nguyen, Jill Sumfest, Kristine C Ashcraft, Rhonda M Cooper-DeHoff

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kendra J GrandeInvitae, Denver, CO 80134, USA.
Rachel DaltonDepartment of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.
Nicolas A MoyerInvitae, Seattle, WA 98121, USA.
Meghan J ArwoodTabula Rasa Healthcare, Moorestown, NJ 08057, USA.
Khoa A NguyenDepartment of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.
Jill SumfestGatorCare, University of Florida, Gainesville, FL 32610, USA.
Kristine C AshcraftInvitae, Seattle, WA 98121, USA.ORCID 0000-0002-6609-0075
Rhonda M Cooper-DeHoffDepartment of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-5198-130X
University of Florida · USInvitae (United States) · US

Funding

NIH HHS TR001427
6 · The paper itself

Abstract

We compared patient cohorts selected for pharmacogenomic testing using a manual method or automated algorithm in a university-based health insurance network. The medication list was compiled from claims data during 4th quarter 2018. The manual method selected patients by number of medications by the health system's list of medications for pharmacogenomic testing. The automated method used YouScript's pharmacogenetic interaction probability (PIP) algorithm to select patients based on the probability that testing would result in detection of one or more clinically significant pharmacogenetic interactions. A total of 6916 patients were included. Patient cohorts selected by each method differed substantially, including size (manual

Indexed as

ambulatory caredrug interactionspharmacogeneticspharmacogenomic testingPrecision medicine

Identifiers

PMID35207649
PMCPMC8878761
OpenAlexW4210495714

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.