Evidence map›Paper›PMID 35207639›Full record

ArticleJournal of personalized medicine2022

Novel

Yejin Lee, Hong Zhang, Figen Seymen, Youn Jung Kim, Yelda Kasimoglu, Mine Koruyucu, James P Simmer, Jan C-C Hu, Jung-Wook Kim

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Drug Discovery Strategies for Kallikrein-Related Peptidases.International journal of molecular sciences · 2025
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Yejin LeeDepartment of Pediatric Dentistry, School of Dentistry & DRI, Seoul National University, Seoul 03080, Korea.
Hong ZhangDepartment of Biologic and Materials Sciences & Prosthodontics, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-4558-9026
Figen SeymenDepartment of Pedodontics, Faculty of Dentistry, Istanbul University, Istanbul 34116, Turkey.ORCID 0000-0001-7010-2035
Youn Jung KimDepartment of Pediatric Dentistry, School of Dentistry & DRI, Seoul National University, Seoul 03080, Korea.
Yelda KasimogluDepartment of Pedodontics, Faculty of Dentistry, Istanbul University, Istanbul 34116, Turkey.ORCID 0000-0003-1022-2486
Mine KoruyucuDepartment of Pedodontics, Faculty of Dentistry, Istanbul University, Istanbul 34116, Turkey.ORCID 0000-0002-2077-5095
James P SimmerDepartment of Biologic and Materials Sciences & Prosthodontics, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA.
Jan C-C HuDepartment of Biologic and Materials Sciences & Prosthodontics, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-9294-0248
Jung-Wook KimDepartment of Pediatric Dentistry, School of Dentistry & DRI, Seoul National University, Seoul 03080, Korea.ORCID 0000-0002-9399-2197
Istanbul University · TRSeoul National University · KRUniversity of Michigan · US

Funding

Proteomics and Genetics of Enamel and DentinR01DE015846 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HU, JAN CHING CHUN · 2004 to 2019
$5.7M
Genetic Mechanisms of Amelogenesis ImperfectaR56DE015846 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HU, JAN CHING CHUN · 2021 to 2021
$402k
National Research Foundation of Korea NRF-2018R1A5A2024418 and NRF-2020R1A2C2100543NIDCR NIH HHS DE015846
6 · The paper itself

Abstract

Amelogenesis imperfecta (AI) is a group of rare genetic diseases affecting the tooth enamel. AI is characterized by an inadequate quantity and/or quality of tooth enamel and can be divided into three major categories: hypoplastic, hypocalcified and hypomaturation types. Even though there are some overlapping phenotypes, hypomaturation AI enamel typically has a yellow to brown discoloration with a dull appearance but a normal thickness indicating a less mineralized enamel matrix. In this study, we recruited four Turkish families with hypomaturation AI and performed mutational analysis using whole exome sequencing. These analyses revealed two novel homozygous mutations in the

Indexed as

amelogenesis imperfectagenetic diseaseshypomaturationkallikrein 4whole exome sequencingzymography

Identifiers

PMID35207639
PMCPMC8878363
OpenAlexW4210805204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.