Evidence map›Paper›PMID 35207576›Full record

ReviewLife (Basel, Switzerland)2022

microRNAs and Inflammatory Immune Response in SARS-CoV-2 Infection: A Narrative Review.

Beatrice Maranini, Giovanni Ciancio, Manuela Ferracin, Rosario Cultrera, Massimo Negrini, Silvia Sabbioni, Marcello Govoni

Open access · goldAbstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Viruses · 2025
    Article
  5. Advancing Ischemic Stroke Prognosis: Key Role of MiR-155 Non-Coding RNA.International journal of molecular sciences · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Host factors of SARS-CoV-2 in infection, pathogenesis, and long-term effects.Frontiers in cellular and infection microbiology · 2024
    Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. The involvement of microRNAs in HCV and HIV infection.Therapeutic advances in vaccines and immunotherapy · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Beatrice MaraniniRheumatology Unit, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-7313-3520
Giovanni CiancioRheumatology Unit, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.
Manuela FerracinDepartment of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, 40138 Bologna, Italy.ORCID 0000-0002-1595-6887
Rosario CultreraInfectious Diseases, Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-7440-6447
Massimo NegriniLaboratorio per le Tecnologie delle Terapie Avanzate (LTTA), Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
Silvia SabbioniDepartment of Life Sciences and Biotechnologies, University of Ferrara, 44121 Ferrara, Italy.
Marcello GovoniRheumatology Unit, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-0499-5773
University of Ferrara · ITUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The current SARS-CoV-2 pandemic has emerged as an international challenge with strong medical and socioeconomic impact. The spectrum of clinical manifestations of SARS-CoV-2 is wide, covering asymptomatic or mild cases up to severe and life-threatening complications. Critical courses of SARS-CoV-2 infection are thought to be driven by the so-called "cytokine storm", derived from an excessive immune response that induces the release of proinflammatory cytokines and chemokines. In recent years, non-coding RNAs (ncRNAs) emerged as potential diagnostic and therapeutic biomarkers in both inflammatory and infectious diseases. Therefore, the identification of SARS-CoV-2 miRNAs and host miRNAs is an important research topic, investigating the host-virus crosstalk in COVID-19 infection, trying to answer the pressing question of whether miRNA-based therapeutics can be employed to tackle SARS-CoV-2 complications. In this review, we aimed to directly address ncRNA role in SARS-CoV-2-immune system crosstalk upon COVID-19 infection, particularly focusing on inflammatory pathways and cytokine storm syndromes.

Indexed as

COVID-19cytokine stormimmune responseinflammatory responselncRNAsmiRNAsncRNAsSARS-CoV-2

Identifiers

PMID35207576
PMCPMC8879390
OpenAlexW4213161857

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.