Evidence map›Paper›PMID 35207531›Full record

ArticleLife (Basel, Switzerland)2022

In Patients with Severe COVID-19, the Profound Decrease in the Peripheral Blood T-Cell Subsets Is Correlated with an Increase of QuantiFERON-TB Gold Plus Indeterminate Rates and Reflecting a Reduced Interferon-Gamma Production.

Alessandra Imeneo, Grazia Alessio, Andrea Di Lorenzo, Laura Campogiani, Alessandra Lodi, Filippo Barreca, Marta Zordan, Virginia Barchi, Barbara Massa, Simona Tedde and 11 more

Open access · goldAbstract read
In one paragraph

Article in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  8. Review
  9. Article
  10. The Pitfalls of Mining for QuantiFERON Gold in Severely Ill Patients With COVID-19.Mayo Clinic proceedings. Innovations, quality & outcomes · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 2 institutions in 1 country.

Alessandra ImeneoDepartment of System Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Grazia AlessioDepartment of System Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Andrea Di LorenzoDepartment of System Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Laura CampogianiInfectious Disease Clinic, Policlinico Tor Vergata, Viale Oxford 81, 00133 Rome, Italy.
Alessandra LodiDepartment of System Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Filippo BarrecaDepartment of System Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Marta ZordanDepartment of System Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Virginia BarchiDepartment of System Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Barbara MassaDepartment of System Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Simona TeddeDepartment of System Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Angela CreaDepartment of System Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Pietro VitaleInfectious Disease Clinic, Policlinico Tor Vergata, Viale Oxford 81, 00133 Rome, Italy.
Ilaria SpallieraInfectious Disease Clinic, Policlinico Tor Vergata, Viale Oxford 81, 00133 Rome, Italy.
Mirko CompagnoInfectious Disease Clinic, Policlinico Tor Vergata, Viale Oxford 81, 00133 Rome, Italy.
Luigi CoppolaInfectious Disease Clinic, Policlinico Tor Vergata, Viale Oxford 81, 00133 Rome, Italy.
Luca DoriInfectious Disease Clinic, Policlinico Tor Vergata, Viale Oxford 81, 00133 Rome, Italy.
Vincenzo MalagninoDepartment of System Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Elisabetta TetiInfectious Disease Clinic, Policlinico Tor Vergata, Viale Oxford 81, 00133 Rome, Italy.
Massimo AndreoniDepartment of System Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Loredana SarmatiDepartment of System Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.ORCID 0000-0003-1452-0333
Marco IannettaDepartment of System Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.ORCID 0000-0002-6938-8627
University of Rome Tor Vergata · ITPoliclinico Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increased rates of indeterminate QuantiFERON-TB Gold Plus Assay (QFT-Plus) were demonstrated in patients hospitalized with Coronavirus Disease (COVID)-19. We aimed to define the prevalence and characteristics of hospitalized COVID-19 patients with indeterminate QFT-Plus. A retrospective study was performed including hospitalized COVID-19 patients, stratified in survivors and non-survivors, non-severe and severe according to the maximal oxygen supply required. Statistical analysis was performed using JASP ver0.14.1 and GraphPad Prism ver8.2.1. A total of 420 patients were included, median age: 65 years, males: 66.4%. The QFT-Plus was indeterminate in 22.1% of patients. Increased rate of indeterminate QFT-Plus was found in non-survivors (

Indexed as

CD3IFNIGRAlymphopeniaQuantiFERON-TB GoldSARS-CoV-2

Identifiers

PMID35207531
PMCPMC8880410
OpenAlexW4210947938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.