ArticleLife (Basel, Switzerland)2022
Preliminary In Vitro Cytotoxicity, Mutagenicity and Antitumoral Activity Evaluation of Graphene Flake and Aqueous Graphene Paste.
Article in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Smart Thermoresponsive Sol-Gel Formulation of Polyhexanide for Rapid and Painless Burn and Wound Management.Polymers · 2025Article
- Assessment of aqueous graphene as a cancer therapeutics delivery system.Scientific reports · 2025Article
- Synthesis and Reactivity of Oligo(ethylene glycol)-Tethered Morita-Baylis-Hillman Dimers in the Formation of Macrocyclic Structures Showing Remarkable Cytotoxicity.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Modern Approach to Testing the Biocompatibility of Osteochondral Scaffolds in Accordance with the 3Rs Principle─PreclinicalACS biomaterials science & engineering · 2025Article
- Cytotoxicity and antibacterial susceptibility assessment of a newly developed pectin-chitosan polyelectrolyte composite for dental implants.Scientific reports · 2024Article
- RepurposingLife (Basel, Switzerland) · 2024Article
- Structuring and De-Structuring of Nanovectors from Algal Lipids: Simulated Digestion, Preliminary Antioxidant Capacity and In Vitro Tests.Pharmaceutics · 2022Article
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Authors and funding
1 author.
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Abstract
This study aimed to determine the in vitro cytotoxicity and mutagenicity of graphene flake (GF) and aqueous graphene paste (AGP) in order to evaluate their potential for application as biomaterials. Furthermore, their antitumor activity against adherent and suspended cells, namely, human breast adenocarcinoma cells (MDA-MB-231), and human monocytes from histiocytic lymphoma (U-937), was investigated. The results demonstrated that GF reduced the viability and proliferation of NIH3T3 immortalized murine fibroblasts for concentrations >0.8 µg/mL and incubation times of 48 and 72 h. AGP showed no toxic effects in any of the tested concentrations and incubation times. The same results were obtained for MDA-MB-231 cells. The viability of the U-937 cells was not affected by either GF or AGP. The Ames test showed that GF and AGP were not genotoxic against
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