Evidence map›Paper›PMID 35207412›Full record

ArticleJournal of clinical medicine2022

Symptom Severity and Health-Related Quality of Life in Patients with Atrial Fibrillation: Findings from the Observational ARENA Study.

Monika Sadlonova, Jochen Senges, Jonas Nagel, Christopher Celano, Caroline Klasen-Max, Martin Borggrefe, Ibrahim Akin, Dierk Thomas, Christopher Jan Schwarzbach, Thomas Kleeman and 8 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Brazilian Atrial Fibrillation Guidelines - 2025.Arquivos brasileiros de cardiologia · 2025
    Article
  2. Observational
  3. Article
  4. Observational
  5. Article
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  7. Health-related quality of life and healthcare costs of symptoms and cardiovascular disease events in patients with atrial fibrillation: a longitudinal analysis of 27 countries from the EURObservational Research Programme on Atrial Fibrillation general long-term registry.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Observational
  8. Article
  9. Observational
  10. Discovery ofBiology · 2023
    Article
  11. Correlation between family function and quality of life in patients with atrial fibrillation.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 10 institutions in 2 countries.

Monika SadlonovaDepartment of Psychosomatic Medicine and Psychotherapy, University of Göttingen Medical Center, 37075 Gottingen, Germany.ORCID 0000-0003-3629-252X
Jochen SengesInstitute of Myocardial Infarction Research, Hospital of Ludwigshafen, 67063 Ludwigshafen, Germany.
Jonas NagelDepartment of Psychosomatic Medicine and Psychotherapy, University of Göttingen Medical Center, 37075 Gottingen, Germany.ORCID 0000-0001-5900-1188
Christopher CelanoDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0003-0547-2851
Caroline Klasen-MaxDepartment of Psychosomatic Medicine and Psychotherapy, University of Göttingen Medical Center, 37075 Gottingen, Germany.
Martin BorggrefeDepartment of Cardiology, Pneumology, Angiology, and Emergency Medicine, University of Mannheim Medical Center, 68167 Mannheim, Germany.
Ibrahim AkinDepartment of Cardiology, Pneumology, Angiology, and Emergency Medicine, University of Mannheim Medical Center, 68167 Mannheim, Germany.
Dierk ThomasGerman Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, 69120 Heidelberg, Germany.
Christopher Jan SchwarzbachDepartment of Neurology, Hospital of Ludwigshafen, 67063 Ludwigshafen, Germany.
Thomas KleemanHospital of Ludwigshafen, 67063 Ludwigshafen, Germany.
Steffen SchneiderInstitute of Myocardial Infarction Research, Hospital of Ludwigshafen, 67063 Ludwigshafen, Germany.
Matthias HochadelInstitute of Myocardial Infarction Research, Hospital of Ludwigshafen, 67063 Ludwigshafen, Germany.
Tim SüselbeckClinic of Cardiology, 67071 Ludwigshafen, Germany.ORCID 0000-0003-2837-3848
Harald SchwackeDiakonissen-Stiftungs-Hospital Speyer, 67346 Speyer, Germany.
Angelika AlonsoDepartment of Neurology, Mannheim Center for Translational Neuroscience, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
Markus HaassDepartment of Cardiology, Theresien Hospital and St. Hedwig Clinic GmbH, 68165 Mannheim, Germany.
Karl-Heinz LadwigDepartment of Psychosomatic Medicine and Psychotherapy, University Hospital Rechts der Isar, Technical University Munich, 81675 Munich, Germany.
Christoph Herrmann-LingenDepartment of Psychosomatic Medicine and Psychotherapy, University of Göttingen Medical Center, 37075 Gottingen, Germany.
Klinikum Ludwigshafen · DEHarvard University · USUniversity of Göttingen · DEUniversity of Mannheim · DEDiakonissenkrankenhaus · DEGerman Centre for Cardiovascular Research · DEHeidelberg University · DESt. Hedwig-Krankenhaus · DETUM Klinikum · DEUniversity Hospital Heidelberg · DE

Funding

Boehringer Ingelheim Foundation n/aGerman Heart Research Foundation n/aStiftung Institut für Herzinfarktforschung n/a
6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with impaired health-related quality of life (HRQoL), high symptom severity, and poor cardiovascular outcomes. Both clinical and psychological factors may contribute to symptom severity and HRQoL in AF.

methodsUsing data from the observational Atrial Fibrillation Rhine-Neckar Region (ARENA) trial, we identified medical and psychosocial factors associated with AF-related symptom severity using European Heart Rhythm Association symptom classification and HRQoL using 5-level EuroQoL- 5D.

resultsIn 1218 AF patients (mean age 71.1 ± 10.5 years, 34.5% female), female sex (OR 3.7,

conclusionsPsychological characteristics, preexisting CAD, and diabetes may play an important role in the identification of individuals at highest risk for impaired HRQoL and high symptom severity in patients with AF.

Indexed as

atrial fibrillationEHRA classhealth-related quality of life

Identifiers

PMID35207412
PMCPMC8877113
OpenAlexW4213046455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.