ArticleJournal of clinical medicine2022
Relation between Serum Creatine Phosphokinase Levels and Acute Kidney Injury among ST-Segment Elevation Myocardial Infarction Patients.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- RNA biomarker signatures for prediction of acute kidney injury in acute coronary syndrome patients undergoing PCI.BMC nephrology · 2026Observational
- Prevalence and prognostic impact of rhabdomyolysis in adults hospitalized with diabetic ketosis: a 10-year single-center cohort study.Endocrine connections · 2026Article
- Article
- Impact of Rhabdomyolysis on Clinical Outcomes in Patients With Acute Myocardial Infarction.Cureus · 2025Article
- Safety, pharmacokinetics, and biological activity of CD4-mimetic BNM-III-170 in SHIV-infected rhesus macaques.Journal of virology · 2025Article
- Improvement of microvascular complications in STZ-diabetic rats treated withBiochemistry and biophysics reports · 2023Article
- Administration of a single dose of lithium ameliorates rhabdomyolysis-associated acute kidney injury in rats.PloS one · 2023Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmong patients with rhabdomyolysis, the leakage of intracellular skeletal muscle content such as creatine phosphokinase (CPK) into the bloodstream has been associated with an increased risk of acute kidney injury (AKI). We evaluated the possible relationship between serum CPK levels and AKI occurrence among patients with myocyte injury secondary to ST-elevation myocardial infarction (STEMI).
methodsWe retrospectively included 2794 patients with STEMI. Patients were stratified according to peak serum CPK levels into mild (<1000 U/L,
resultsThe overall occurrence of AKI was 10.4%. Incidence of AKI showed a gradual increase between patients with mild, moderate, and severe serum CPK level elevations (7.8% vs. 11% vs. 26% respectively;
conclusionsAmong STEMI patients, elevated CPK levels were associated with AKI. This association is presumably independent; however, it remains unclear whether it is due to direct toxic (myoglobin-related) or hemodynamic effects (poor left ventricular function). Further studies are required to reveal the underlying mechanism.
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