ArticleJournal of clinical medicine2022
Association of Neuroretinal Thinning and Microvascular Changes with Hypertension in an Older Population in Southern Italy.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Oculomics approaches using retinal imaging to predict mental health disorders: a systematic review and meta-analysis.International ophthalmology · 2025Pooled it
- Reference Percentiles for Macular Vessel Density by OCT Angiography and Their Association with Systemic Diseases in Chinese Adults.Ophthalmology science · 2026Article
- Evaluating the effect of systemic hypertension on retinal, optic nerve head microvasculature and field of vision using optical coherence tomography angiography and visual field analyzer.BMC ophthalmology · 2025Observational
- Effect of Circadian Blood Pressure Variations on Retinal Microvascular Structures: Optical Coherence Tomography Angiography Analysis with the Nighttime Divided into Subintervals (Retinal Dawn Pattern).Medicina (Kaunas, Lithuania) · 2025Article
- Risk factors for pupil changes in patients with diabetic retinopathy and cataract after phacoemulsification with intraocular lens implantation.BMC ophthalmology · 2025Observational
- Retinal Microangiopathy as a Marker of Coronary Atherosclerotic Heart Disease.International journal of general medicine · 2025Review
- Monitoring Progression in Hypertensive Patients with Dyslipidemia Using Optical Coherence Tomography Angiography: Can A.I. Be Improved?Journal of clinical medicine · 2024Article
- Psychiatry and sensation: the epigenetic links.Epigenomics · 2024Review
- Retinal Microvasculature and Neural Changes and Dietary Patterns in an Older Population in Southern Italy.International journal of environmental research and public health · 2023Article
- Variation in Retinal Nerve Fiber Layer and Ganglion Cell Complex Associated With Optic Nerve Head Size in Healthy Eyes.Translational vision science & technology · 2023Observational
- Mapping Retinal Abnormalities in Psychosis: Meta-analytical Evidence for Focal Peripapillary and Macular Reductions.Schizophrenia bulletin · 2022Article
- Editorial: Imaging in Ophthalmology.Journal of clinical medicine · 2022Article
- Liver fibrosis and retinal features in an older Mediterranean population: Results from the Salus in Apulia study.Frontiers in neuroscience · 2022Article
- A two-year longitudinal study of retinal vascular impairment in patients with amnestic mild cognitive impairment.Frontiers in aging neuroscience · 2022Article
- Optical coherence tomography angiography in cardiovascular disease.Progress in cardiovascular diseasesReview
Corrections and comments
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Authors and funding
22 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundRetinal microvasculature assessment at capillary level may potentially aid the evaluation of early microvascular changes due to hypertension. We aimed to investigate associations between the measures obtained using optical coherence tomography (OCT) and OCT-angiography (OCT-A) and hypertension, in a southern Italian older population.
methodsWe performed a cross-sectional analysis from a population-based study on 731 participants aged 65 years+ subdivided into two groups according to the presence or absence of blood hypertension without hypertensive retinopathy. The average thickness of the ganglion cell complex (GCC) and the retinal nerve fiber layer (RNFL) were measured. The foveal avascular zone area, vascular density (VD) at the macular site and of the optic nerve head (ONH) and radial peripapillary capillary (RPC) plexi were evaluated. Logistic regression was applied to assess the association of ocular measurements with hypertension.
resultsGCC thickness was inversely associated with hypertension (odds ratio (OR): 0.98, 95% confidence interval (CI): 0.97-1). A rarefaction of VD of the ONH plexus at the inferior temporal sector (OR: 0.95, 95% CI: 0.91-0.99) and, conversely, a higher VD of the ONH and RPC plexi inside optic disc (OR: 1.07, 95% CI: 1.04-1.10; OR: 1.04, 95% CI: 1.02-1.06, respectively) were significantly associated with hypertension.
conclusionA neuroretinal thinning involving GCC and a change in capillary density at the peripapillary network were related to the hypertension in older patients without hypertensive retinopathy. Assessing peripapillary retinal microvasculature using OCT-A may be a useful non-invasive approach to detect early microvascular changes due to hypertension.
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